Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6289562 | 0.75 | ALDH1A1 (0.53) | MAPTGAAMAPK1ALDH1A1MEN1 | |
| SCHEMBL15075229 | 0.74 | MAPT (0.47) | MAPTGAAMAPK1HCAR3ESR1 | |
| SCHEMBL2120103 | 0.74 | HCAR3 (0.57) | MAPTGAAMAPK1HCAR3ESR1 | |
| Bromide SCHEMBL6289517 | 0.73 | KMT2A (0.49) | MAPTALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL3117262 | 0.73 | GAA (0.50) | MAPTGAAMAPK1HCAR3ESR1 | |
| SCHEMBL19354873 | 0.71 | CA12 (0.56) | MAPTMAPK1ESR1ALDH1A1MEN1 | |
| SCHEMBL23693239 | 0.70 | GAA (0.50) | MAPTGAAMAPK1HCAR3ESR1 | |
| SCHEMBL10355547 | 0.69 | NPC1 (0.58) | MAPTGAAMAPK1ALDH1A1MEN1 | |
| Bromide SCHEMBL6289071 | 0.69 | ALDH1A1 (0.56) | MAPTGAAMAPK1ALDH1A1MEN1 | |
| SCHEMBL10473157 | 0.69 | KMT2A (0.42) | MAPTGAAMAPK1HCAR3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900250-B2 | Polymerizable composition | TOYO INK MFG. CO., LTD. (JP) | 2005-05-31 | — | — | US | disclosed |
| US-20030212162-A1 | Photopolymerization using photoinitiators | TOYO INK MFG. CO., LTD. (JP) | 2003-11-13 | — | — | US | disclosed |