Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP6V1B1 | P15313 | 5/20 | 0.80 |
| ▸ | ATP6AP1 | Q15904 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345939 | 0.90 | ATP6V1B1 (0.64) | ATP6V1B1ATP6AP1HRH4HRH3SMN1; SMN2 | |
| SCHEMBL8345934 | 0.90 | ATP6V1B1 (0.64) | ATP6V1B1ATP6AP1HRH4HRH3SMN1; SMN2 | |
| SCHEMBL8345943 | 0.90 | ATP6V1B1 (0.64) | ATP6V1B1ATP6AP1HRH4HRH3SMN1; SMN2 | |
| SCHEMBL6291679 | 0.88 | ATP6V1B1 (0.75) | ATP6V1B1ATP6AP1MEN1KMT2AALDH1A1 | |
| SCHEMBL6291675 | 0.88 | ATP6V1B1 (0.75) | ATP6V1B1ATP6AP1MEN1KMT2AALDH1A1 | |
| SCHEMBL6291678 | 0.88 | ATP6V1B1 (0.75) | ATP6V1B1ATP6AP1MEN1KMT2AALDH1A1 | |
| SCHEMBL6292835 | 0.82 | ATP6V1B1 (0.88) | ATP6V1B1ATP6AP1MAPTPYGLALDH1A1 | |
| SCHEMBL6292833 | 0.82 | ATP6V1B1 (0.88) | ATP6V1B1ATP6AP1MAPTPYGLALDH1A1 | |
| SCHEMBL6292838 | 0.82 | ATP6V1B1 (0.88) | ATP6V1B1ATP6AP1MAPTPYGLALDH1A1 | |
| SCHEMBL8053300 | 0.80 | ATP6V1B1 (0.56) | ATP6V1B1SMN1; SMN2MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981525-A | FOR THERAPY OR PROPHYLAXIS OF OSTEOPOROSIS,TUMOURS, ULCERS, AUTOIMMUNE DISEASES, LIPIDEMIC DISORDERS, HYPERCHOLESTEROLEMIC AND ATHEROSCLEROTIC DISEASES, AIDS ALZHEIMER'S DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |