Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.38 |
| ▸ | CA1 | P00915 | 6/20 | 0.38 |
| ▸ | CA9 | Q16790 | 6/20 | 0.38 |
| ▸ | CA5A | P35218 | 5/20 | 0.38 |
| ▸ | CA7 | P43166 | 5/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.38 |
| ▸ | CA4 | P22748 | 4/20 | 0.38 |
| ▸ | CA6 | P23280 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NT5E | P21589 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL160212 | 0.86 | — | — | |
| SCHEMBL1644673 | 0.84 | CA2 (0.46) | CA2CA1CA9CA5ACA7 | |
| Sulfamide SCHEMBL27475146 | 0.81 | CA2 (0.55) | CA2CA1CA9CA5ACA7 | |
| Sulfamide SCHEMBL27491894 | 0.81 | — | — | |
| SCHEMBL1804507 | 0.80 | — | — | |
| SCHEMBL1805054 | 0.78 | — | — | |
| SCHEMBL10622461 | 0.76 | LMNA (0.53) | CA2CA1CA9CA5ACA7 | |
| SCHEMBL1869757 | 0.76 | CA2 (0.47) | CA2TSHRLMNA | |
| SCHEMBL9952155 | 0.76 | CA2 (0.47) | CA2TSHRLMNA | |
| SCHEMBL1164487 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268634-A2 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND RELATED COMPOUNDS USING NOVEL INTERMEDIATES | Actavis Group PTC EHF (IS) | 2011-01-05 | — | — | EP | claimed |
| WO-2009112954-A2 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND RELATED COMPOUNDS USING NOVEL INTERMEDIATES | ACTAVIS GROUP PTC EHF (IS) | 2009-09-17 | — | — | WO | claimed |
| EP-1254121-B1 | PREPARATION OF SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2006-02-01 | — | — | EP | claimed |
| CN-1178921-C | Preparation of sulfonamides | - | 2004-12-08 | — | — | CN | claimed |
| CN-1425007-A | Preparation of sulfonamides | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | CN | claimed |
| EP-1254121-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-06 | — | — | EP | claimed |
| WO-2001055120-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-02 | — | — | WO | claimed |
| US-6136971-A | Preparation of sulfonamides | ROCHE COLORADO CORPORATION (US) | 2000-10-24 | — | — | US | claimed |
| CN-114907275-A | Preparation method of bosentan | 武汉工程大学 | 2022-08-16 | — | — | CN | disclosed |
| EP-2245018-B1 | PROCESS FOR PREPARING BOSENTAN | GENERICS UK LTD (GB) | 2017-08-30 | — | — | EP | disclosed |
| EP-2738165-B1 | Method by means of phase transfer catalysis | WÖRWAG PHARMA GMBH & CO KG (DE) | 2016-10-12 | — | — | EP | disclosed |
| US-9296705-B2 | 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2(2-pyrimidinyl)-pyrimidine-4-yl)-benzen esulfonamide sodium | DAVULURI RAMAMOHAN RAO (IN) | 2016-03-29 | — | — | US | disclosed |
| US-20150232430-A1 | 4-TERT-BUTYL-N-[6-(2-HYDROXYETHOXY)-5-(2-METHOXYPHENOXY)-2(2-PYRIMIDINYL)-PYRIMIDINE-4-YL)-BENZEN ESULFONAMIDE SODIUM | Rao, Davuluri Ramamohan (IN) | 2015-08-20 | — | — | US | disclosed |
| EP-2550256-B1 | PROCESS FOR THE PREPARATION OF BOSENTAN | LESVI LABORATORIOS SL (ES) | 2015-07-15 | — | — | EP | disclosed |
| CN-1178921-C | Preparation of sulfonamides | - | 2004-12-08 | — | — | CN | disclosed |
| CN-1523084-A | Additive for improving fuel lubricating property and application thereof | 中国石油天然气股份有限公司 | 2004-08-25 | — | — | CN | disclosed |
| CN-1425007-A | Preparation of sulfonamides | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | CN | disclosed |
| EP-1254121-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001055120-A1 | PREPARATION OF SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-02 | — | — | WO | disclosed |
| US-6136971-A | Preparation of sulfonamides | ROCHE COLORADO CORPORATION (US) | 2000-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150232430-A1 | 4-TERT-BUTYL-N-[6-(2-HYDROXYETHOXY)-5-(2-METHOXYPHENOXY)-2(2-PYRIMIDINYL)-PYRIMIDINE-4-YL)-BENZEN ESULFONAMIDE SODIUM | EDNRB, ECE2, EDNRA | CA2 1862/4885CA1 4866/4885CA9 4387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.