Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152589 | 0.84 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2NPSR1LMNA | |
| SCHEMBL6153378 | 0.84 | ROCK2 (0.37) | HSD17B10ALDH1A1CASP1CASP7TDP2 | |
| SCHEMBL5778037 | 0.83 | MAPT (0.41) | HSD17B10ALDH1A1CASP1CASP7TSHR | |
| SCHEMBL5773899 | 0.81 | CCR6 (0.43) | HSD17B10KDM4EHTTSMN1; SMN2MAPK1 | |
| SCHEMBL5774622 | 0.80 | MEN1 (0.42) | ALDH1A1TSHRKDM4EMAPK1MEN1 | |
| SCHEMBL5776589 | 0.80 | TP53 (0.41) | HSD17B10ALDH1A1CASP1CASP7TDP2 | |
| SCHEMBL5772617 | 0.79 | NPC1 (0.35) | HSD17B10ALDH1A1CASP1CASP7L3MBTL1 | |
| SCHEMBL5775592 | 0.77 | KDM4E (0.40) | HSD17B10ALDH1A1CASP1CASP7TDP2 | |
| SCHEMBL6152992 | 0.75 | PLA2G2A (0.32) | HSD17B10ALDH1A1CASP1CASP7KDM4E | |
| SCHEMBL6581680 | 0.75 | ALDH1A1 (0.36) | HSD17B10ALDH1A1TSHRL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943181-B2 | Use of substituted gamma-lactone compounds as pharmaceutical preparations | GRUNENTHAL GMBH (DE) | 2005-09-13 | — | — | US | disclosed |