Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30921001 | 0.91 | ALDH1A1 (0.47) | ALDH1A1TDP1EPHX2KDM4EHPGD | |
| SCHEMBL27260554 | 0.83 | EPHX2 (0.51) | EPHX2KDM4EKEAP1NFE2L2HPGD | |
| SCHEMBL8848512 | 0.80 | EPHX2 (0.55) | ALDH1A1EPHX2KDM4EKEAP1NFE2L2 | |
| SCHEMBL24146308 | 0.80 | EPHX2 (0.49) | EPHX2KDM4EKEAP1NFE2L2HPGD | |
| SCHEMBL25567742 | 0.79 | EPHX2 (0.48) | EPHX2KDM4EKEAP1NFE2L2HPGD | |
| SCHEMBL24146116 | 0.79 | EPHX2 (0.48) | EPHX2KDM4EKEAP1NFE2L2HPGD | |
| SCHEMBL7724890 | 0.78 | EPHX2 (0.57) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL6360164 | 0.78 | EPHX2 (0.53) | ALDH1A1EPHX2KDM4EKEAP1NFE2L2 | |
| SCHEMBL15680573 | 0.77 | KEAP1 (0.66) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL628952 | 0.77 | KEAP1 (0.57) | EPHX2KEAP1NFE2L2HPGDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986384-B1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2012-02-22 | — | — | EP | disclosed |
| EP-0986384-B1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 2012-02-22 | — | — | EP | disclosed |
| US-6310095-B1 | INHIBITING OR TREATING CANCER, TREATING INTIMAL HYPERPLASIA ASSOCIATED WITH RESTENOSIS AND ATHEROSCLEROSIS, INHIBITING POST-TRANSLATIONAL MODIFICATION OF ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE AND/OR GERANYLGERANYLTRANSFERASE | UNIVERSITY OF PITTSBURGH | 2001-10-30 | — | — | US | disclosed |