Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629341 | 0.83 | ALDH1A1 (0.51) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL27294619 | 0.81 | EPHX2 (0.35) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL24146308 | 0.80 | EPHX2 (0.49) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL25567742 | 0.79 | EPHX2 (0.48) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL24146116 | 0.79 | EPHX2 (0.48) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL7724890 | 0.78 | EPHX2 (0.57) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL15680573 | 0.77 | KEAP1 (0.66) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL8848512 | 0.77 | EPHX2 (0.55) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL628894 | 0.77 | EPHX2 (0.55) | EPHX2KEAP1NFE2L2HPGDEPHX1 | |
| SCHEMBL13527977 | 0.76 | EPHX2 (0.54) | EPHX2KEAP1NFE2L2HPGDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023242597-A1 | BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2023-12-21 | — | — | WO | disclosed |