Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.71 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.71 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.71 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL2473794 | 1.00 | — | — | |
| Glycine SCHEMBL27533136 | 1.00 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL19326549 | 1.00 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL20528834 | 1.00 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL27552443 | 1.00 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL599168 | 0.96 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL844613 | 0.96 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL29055914 | 0.96 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL782087 | 0.96 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL29055907 | 0.96 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1424373-B1 | Hydrophilized powder and a composition comprising the same | SHINETSU CHEMICAL CO (JP) | 2012-02-22 | — | — | EP | disclosed |
| US-7285290-B2 | Hydrophilized powder and a composition comprising the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2007-10-23 | — | — | US | disclosed |
| EP-1424373-A2 | Hydrophilized powder and a composition comprising the same | Shin-Etsu Chemical Company, Ltd. (JP) | 2004-06-02 | — | — | EP | disclosed |