Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.77 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.77 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.77 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.40 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.40 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.40 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL844613 | 1.00 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL3028173 | 1.00 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL699841 | 1.00 | — | — | |
| Glycine SCHEMBL782087 | 1.00 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL29055907 | 1.00 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL29055914 | 1.00 | GLRA1 (0.77) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL19326549 | 0.96 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL20528834 | 0.96 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL2473794 | 0.96 | — | — | |
| Glycine SCHEMBL629430 | 0.96 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2GABRR1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 455 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283179-B1 | SOLID SKIN CARE EMULSION COMPRISING SOLID AND LIQUID LIPIDS | BEIERSDORF AG (DE) | 2021-01-27 | — | — | EP | claimed |
| US-20200121566-A1 | Methods of Making Solid Stick Antiperspirant Compositions | PROCTER & GAMBLE (US) | 2020-04-23 | — | — | US | claimed |
| CN-110114052-A | Extruded antiperspirant compositions having improved efficacy | 高露洁-棕榄公司 | 2019-08-09 | — | — | CN | claimed |
| EP-2900203-B1 | METHODS OF MAKING SOLID STICK ANTIPERSPIRANT COMPOSITIONS | PROCTER & GAMBLE (US) | 2018-09-12 | — | — | EP | claimed |
| EP-2900199-B1 | SOLID STICK ANTIPERSPIRANT COMPOSITIONS | PROCTER & GAMBLE (US) | 2018-09-05 | — | — | EP | claimed |
| US-10016343-B2 | Solid stick antiperspirant compositions | THE PROCTER & GAMBLE COMPANY (US) | 2018-07-10 | — | — | US | claimed |
| EP-3283179-A1 | SOLID SKIN CARE EMULSION COMPRISING SOLID AND LIQUID LIPIDS | Beiersdorf AG (DE) | 2018-02-21 | — | — | EP | claimed |
| CN-102470080-B | Catalysed dye systems | 利兹大学 | 2017-08-29 | — | — | CN | claimed |
| US-9724543-B2 | Antiperspirant products comprising active antiperspirant compounds surface treated with hydrophobizing agents and methods for manufacturing the same | Henkel IP & Holding GmbH (DE) | 2017-08-08 | — | — | US | claimed |
| WO-2016155867-A1 | SOLID SKIN CARE EMULSION COMPRISING SOLID AND LIQUID LIPIDS | BEIERSDORF AG (DE) | 2016-10-06 | — | — | WO | claimed |
| WO-2005020939-A2 | SKIN CARE COSMETIC COMPOSITIONS AND METHODS FOR MICROEMULSIFICATION OF SEBUM ON CONTACT | UNILEVER PLC (GB) | 2005-03-10 | — | — | WO | claimed |
| US-20050048025-A1 | Skin care cosmetic compositions and methods for microemulsification of sebum on contact | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2005-03-03 | — | — | US | claimed |
| US-6835373-B2 | A particulate antiperspirant active having a metal to chloride molar ratio of <= to about 1.3, a volatile solvent, a low surface tension nonvolatile solvent and a suspending agent | THE PROCTER & GAMBLE COMPANY | 2004-12-28 | — | — | US | claimed |
| WO-2004006883-A1 | SKIN CARE COSMETIC COMPOSITIONS CONTAINING CARBOXYALKYLATES OF BRANCHED ALCOHOLS AND/OR ALKOXYLATES THEREOF | UNILEVER PLC (GB) | 2004-01-22 | — | — | WO | claimed |
| WO-2004006877-A1 | NON-IRRITATING ANTIPERSPIRANT COMPOSITIONS CONTAINING ACIDIC ANTIPERSPIRANT ACTIVE | THE PROCTER & GAMBLE COMPANY (US) | 2004-01-22 | — | — | WO | claimed |
| US-20040013631-A1 | Skin care cosmetic compositions containing carboxyalkylates of branched alcohols and/or alkoxylates thereof | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO | 2004-01-22 | — | — | US | claimed |
| US-20040009133-A1 | Non-irritating antiperspirant compositions containing acidic antiperspirant active | THE PROCTER & GAMBLE COMPANY | 2004-01-15 | — | — | US | claimed |
| CN-1102381-C | Antiperspirant roll-on compositions | CLAIROL INC (US) | 2003-03-05 | — | — | CN | claimed |
| US-5676936-A | INCORPORATING A COMPOUND HAVING A BASIC NITROGEN FUNCTION OR A BASIC OXYGEN FUNCTION | CHESEBROUGH-POND'S U.S.A. CO. (US) | 1997-10-14 | — | — | US | claimed |
| US-4774079-A | BUFFERS, ESPECIALLY GLYCINE, ACIDITY | BRISTOL-MYERS COMPANY (US) | 1988-09-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009133-A1 | Non-irritating antiperspirant compositions containing acidic antiperspirant active | SIGMAR1, PTPN6, PTPN14 | GLRA1 767/4885SLC6A9 964/4885OR51E2 204/4885 |
| US-10016343-B2 | Solid stick antiperspirant compositions | SUPT16H, SSRP1, U2SURP | GLRA1 3241/4885SLC6A9 1706/4885OR51E2 692/4885 |
| US-20040013631-A1 | Skin care cosmetic compositions containing carboxyalkylates of branched alcohols and/or alkoxylates thereof | CUTA, YAP1, EBP | GLRA1 1846/4885SLC6A9 3271/4885OR51E2 125/4885 |
| US-20200121566-A1 | Methods of Making Solid Stick Antiperspirant Compositions | U2SURP, SUPT16H, RNGTT | GLRA1 3511/4885SLC6A9 1549/4885OR51E2 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.