Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255579 | 0.85 | KDM4E (0.63) | AGTR1MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL14698798 | 0.82 | AGTR1 (0.62) | AGTR1MEN1KMT2ASIRT2KDM4E | |
| SCHEMBL1499127 | 0.81 | AGTR1 (0.60) | AGTR1MEN1KMT2ASIRT2KDM4E | |
| SCHEMBL8047226 | 0.80 | KMT2A (0.56) | AGTR1MEN1KMT2ASIRT2KDM4E | |
| SCHEMBL3413963 | 0.80 | AGTR1 (0.56) | AGTR1MEN1KMT2ASIRT2KDM4E | |
| SCHEMBL3441356 | 0.79 | AGTR1 (0.54) | AGTR1MEN1KMT2ASIRT2KDM4E | |
| SCHEMBL24050222 | 0.79 | AGTR1 (0.41) | AGTR1MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL8943473 | 0.78 | AGTR1 (0.57) | AGTR1MEN1KMT2ASIRT2KDM4E | |
| Hydrochloric Acid SCHEMBL5389527 | 0.77 | AGTR1 (0.53) | AGTR1MEN1KMT2ASIRT2KDM4E | |
| SCHEMBL31326903 | 0.77 | AGTR1 (0.60) | AGTR1MEN1KMT2ASIRT2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872727-B1 | Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation | PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2005-03-29 | — | — | US | disclosed |