Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 17/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628694 | 0.84 | CCR2 (0.48) | CCR2KCNH2 | |
| SCHEMBL629389 | 0.82 | CCR2 (0.47) | CCR2KCNH2 | |
| SCHEMBL631768 | 0.80 | CCR2 (0.45) | CCR2KCNH2 | |
| SCHEMBL634339 | 0.80 | CCR2 (0.52) | CCR2 | |
| SCHEMBL633026 | 0.80 | CCR2 (0.52) | CCR2KCNH2 | |
| SCHEMBL3460068 | 0.79 | CCR2 (0.63) | CCR2KCNH2 | |
| SCHEMBL633414 | 0.79 | CCR2 (0.47) | CCR2 | |
| SCHEMBL632467 | 0.78 | TRPV1 (0.45) | CCR2KCNH2 | |
| SCHEMBL632419 | 0.74 | CCR2 (0.47) | CCR2KCNH2 | |
| SCHEMBL629038 | 0.74 | CCR2 (0.52) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419417-A1 | 4-AZETIDINYL-1-HETEROARYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | Janssen Pharmaceutica, N.V. (BE) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010121011-A1 | 4-AZETIDINYL-1-HETEROARYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-21 | — | — | WO | disclosed |