Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846592 | 0.91 | MAPT (0.33) | TEAD1MAPTMMP3MMP1MMP2 | |
| SCHEMBL5981485 | 0.82 | BCL2L1 (0.32) | MAPTMMP3MMP1MMP2MMP9 | |
| SCHEMBL7450756 | 0.82 | CYP2C8 (0.33) | MAPTMMP3MMP1MMP2MMP9 | |
| SCHEMBL7584054 | 0.72 | KMT2A (0.39) | MMP2MMP13BCL2L1MCL1MEN1 | |
| SCHEMBL5981554 | 0.71 | MCL1 (0.39) | TEAD1MAPTLMNABCL2L1MCL1 | |
| SCHEMBL5996194 | 0.70 | CYP2C8 (0.40) | LMNABCL2L1MCL1GLAATM | |
| SCHEMBL8179444 | 0.69 | MCL1 (0.43) | BCL2L1MCL1GLA | |
| SCHEMBL2574445 | 0.68 | MMP2 (0.39) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7455250 | 0.68 | ADAM17 (0.37) | MAPTMMP3MMP1MMP2MMP9 | |
| SCHEMBL2586972 | 0.66 | RORC (0.36) | TEAD1MAPTMMP2MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6846954-B2 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 2005-01-25 | — | — | US | disclosed |