Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.57 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | GRK2 | P25098 | 4/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6387973 | 0.83 | MMP13 (0.70) | MMP13HSD17B13ROCK2ROCK1GRK2 | |
| SCHEMBL31742392 | 0.81 | HTT (0.58) | MMP13HSD17B13ROCK2ROCK1GRK2 | |
| SCHEMBL6296274 | 0.79 | MMP13 (0.63) | MMP13HSD17B13GRK2SMN1; SMN2 | |
| SCHEMBL5617838 | 0.75 | MAOB (0.50) | ROCK2ROCK1GRK2GRK1SMN1; SMN2 | |
| SCHEMBL6295992 | 0.75 | MMP13 (0.67) | MMP13 | |
| SCHEMBL5312149 | 0.75 | HDAC3 (0.61) | MMP13GRK2GRK5GRK1SMN1; SMN2 | |
| SCHEMBL2611277 | 0.74 | MMP13 (0.59) | MMP13HSD17B13GRK2 | |
| SCHEMBL6297436 | 0.74 | MMP13 (0.56) | MMP13GRK2SMN1; SMN2L3MBTL1 | |
| SCHEMBL6218212 | 0.74 | MAPK14 (0.52) | MMP13ROCK2ROCK1GRK2SMN1; SMN2 | |
| SCHEMBL6302786 | 0.74 | MMP13 (0.51) | MMP13HSD17B13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894057-B2 | Oxo-azabicyclic compounds | WARNER-LAMBERT COMPANY (US) | 2005-05-17 | — | — | US | disclosed |
| US-6747147-B2 | INHIBITORS OF TYPE-13 MATRIX METTALOPROTEASE. RHEUMATOID ARTHRITIS OR OSTEOARTHRITIS, AS WELL AS CERTAIN PROLIFERATIVE CONDITIONS SUCH AS CANCERS, PARTICULARLY HUMAN BREAST CANCER | WARNER-LAMBERT COMPANY | 2004-06-08 | — | — | US | disclosed |
| US-20030220355-A1 | Oxo-azabicyclic compounds | GAUDILLIERE BERNARD (FR) | 2003-11-27 | — | — | US | disclosed |
| US-20030216402-A1 | Oxo-azabicyclic compounds | GAUDILLIERE BERNARD (FR) | 2003-11-20 | — | — | US | disclosed |
| WO-2003076416-A1 | OXO AZABICYCLIC COMPOUNDS | WARNER-LAMBERT COMPANY LLC (US) | 2003-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216402-A1 | Oxo-azabicyclic compounds | MMP13, CYP2A13, XDH | MMP13 1/4885HSD17B13 106/4885ROCK2 2869/4885 |
| US-20030220355-A1 | Oxo-azabicyclic compounds | MMP13, CYP2A13, CA13 | MMP13 1/4885HSD17B13 89/4885ROCK2 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.