Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.58 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 6/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6292096 | 1.00 | ESR1 (0.58) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6291888 | 1.00 | ESR1 (0.58) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4603155 | 0.99 | ESR1 (0.56) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6856417 | 0.97 | ESR1 (0.58) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6850407 | 0.97 | ESR1 (0.58) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8596393 | 0.97 | ESR1 (0.58) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL6856893 | 0.97 | ESR1 (0.58) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4605018 | 0.96 | ESR1 (0.56) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4605710 | 0.96 | ESR1 (0.56) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4607327 | 0.94 | ESR1 (0.56) | ESR1AKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6977129-B2 | Charge control agent, toner using same developer containing the toner and developing device containing the developer | RICOH COMPANY, LTD. (JP) | 2005-12-20 | — | — | US | disclosed |
| US-20030162018-A1 | Charge control agent, toner using same developer containing the toner and developing device containing the developer | TAKEMOTO YUSHI KABUSHIKI KAISHA (JP) | 2003-08-28 | — | — | US | disclosed |