Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.53 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.38 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.35 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GYS1 | P13807 | 2/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6299232 | 1.00 | HTR2C (0.53) | HTR2CALDH1A1KDM4EHPGDHSD17B10 | |
| Fumaric Acid SCHEMBL6299549 | 0.85 | KDM4E (0.38) | ALDH1A1KDM4EHPGDHSD17B10PMP22 | |
| Fumaric Acid SCHEMBL6299546 | 0.85 | KDM4E (0.38) | ALDH1A1KDM4EHPGDHSD17B10PMP22 | |
| Fumaric Acid SCHEMBL6974126 | 0.81 | HTR2C (0.82) | HTR2CALDH1A1KDM4EHPGDHSD17B10 | |
| Fumaric Acid SCHEMBL6974122 | 0.81 | HTR2C (0.82) | HTR2CALDH1A1KDM4EHPGDHSD17B10 | |
| Oxalic Acid SCHEMBL6305149 | 0.80 | HTR2C (0.64) | HTR2CALDH1A1KDM4EHPGDHSD17B10 | |
| Oxalic Acid SCHEMBL6304609 | 0.80 | HTR2C (0.64) | HTR2CALDH1A1KDM4EHPGDHSD17B10 | |
| Fumaric Acid SCHEMBL6298023 | 0.79 | HTR2C (0.44) | HTR2CALDH1A1LMNAXIAPBIRC2 | |
| Fumaric Acid SCHEMBL6298022 | 0.79 | HTR2C (0.44) | HTR2CALDH1A1LMNAXIAPBIRC2 | |
| Fumaric Acid SCHEMBL6298072 | 0.79 | RAD52 (0.34) | HTR2CGYS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |