Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 7/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2095763 | 0.74 | NFKB1 (0.46) | NFKB1MAOBNFE2L2BACE1MEN1 | |
| SCHEMBL2095766 | 0.74 | NFKB1 (0.46) | NFKB1MAOBNFE2L2BACE1MEN1 | |
| SCHEMBL11845156 | 0.72 | TAS2R14 (0.41) | NFKB1TAS2R14MAOBLMNAP4HB | |
| SCHEMBL17761027 | 0.72 | TAS2R14 (0.44) | NFKB1TAS2R14MAOBMEN1LMNA | |
| SCHEMBL27832515 | 0.71 | TAS2R14 (0.41) | NFKB1TAS2R14MAOBBACE1MEN1 | |
| SCHEMBL1041748 | 0.70 | TAS2R14 (0.46) | TAS2R14IDO1LMNA | |
| SCHEMBL431986 | 0.70 | HSD11B1 (0.47) | IDO1MEN1KMT2A | |
| SCHEMBL5704312 | 0.70 | HSD11B1 (0.47) | IDO1MEN1KMT2A | |
| SCHEMBL8956668 | 0.67 | NFKB1 (0.38) | NFKB1MAOBNFE2L2BACE1IDO1 | |
| SCHEMBL8956948 | 0.67 | NFKB1 (0.38) | NFKB1MAOBNFE2L2BACE1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| US-6881733-B1 | Serotonergic benzofurans | ELI LILLY AND COMPANY (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1204659-B1 | SEROTONERGIC BENZOFURANS | LILLY CO ELI (US) | 2003-11-26 | — | — | EP | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |