Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298600 | 0.93 | POLB (0.42) | POLBSMN1; SMN2ALDH1A1RAB9ATDP1 | |
| SCHEMBL6298803 | 0.90 | ALDH1A1 (0.41) | POLBSMN1; SMN2ALDH1A1RAB9ATDP1 | |
| SCHEMBL6298817 | 0.86 | ALDH1A1 (0.38) | POLBSMN1; SMN2ALDH1A1RAB9ATDP1 | |
| SCHEMBL6579177 | 0.85 | MAPT (0.36) | POLBSMN1; SMN2ALDH1A1RAB9ATDP1 | |
| SCHEMBL6992434 | 0.85 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1RAB9AMAPTHTT | |
| SCHEMBL9116925 | 0.79 | RAB9A (0.46) | POLBSMN1; SMN2ALDH1A1RAB9ATDP1 | |
| SCHEMBL6298823 | 0.79 | MAPT (0.59) | ALDH1A1TDP1NPSR1MAPTHTT | |
| SCHEMBL837180 | 0.77 | IDO1 (0.37) | ALDH1A1RAB9ATSHR | |
| SCHEMBL5961419 | 0.76 | ALDH1A1 (0.46) | POLBSMN1; SMN2ALDH1A1RAB9ATDP1 | |
| SCHEMBL10336593 | 0.74 | RAB9A (0.46) | POLBSMN1; SMN2ALDH1A1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1413302-A2 | Substituted guanidines for the treatment of pain | Kadmus Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | claimed |
| JP-2003525213-A | — | — | 2003-08-26 | — | — | JP | claimed |
| EP-1202718-A2 | SUBSTITUTED GUANIDINES FOR THE TREATMENT OF CANCER AND PAIN | Kadmus Pharmaceuticals, Inc. (US) | 2002-05-08 | — | — | EP | claimed |
| WO-2001007029-A2 | SUBSTITUTED GUANIDINES AND THE USE THEREOF | KADMUS PHARMACEUTICALS, INC. (US) | 2001-02-01 | — | — | WO | claimed |
| US-6875759-B1 | Substituted guanidines and the use thereof | KADMUS PHARMACEUTICALS (US) | 2005-04-05 | — | — | US | disclosed |
| EP-1413302-A2 | Substituted guanidines for the treatment of pain | Kadmus Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-1202718-A2 | SUBSTITUTED GUANIDINES FOR THE TREATMENT OF CANCER AND PAIN | Kadmus Pharmaceuticals, Inc. (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001007029-A2 | SUBSTITUTED GUANIDINES AND THE USE THEREOF | KADMUS PHARMACEUTICALS, INC. (US) | 2001-02-01 | — | — | WO | disclosed |