Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.39 |
| ▸ | KIF11 | P52732 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PGK2 | P07205 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5720508 | 0.77 | TSHR (0.58) | TSHRALDH1A1CYP1A2PTPN1CA1 | |
| SCHEMBL4219815 | 0.77 | TSHR (0.58) | TSHRALDH1A1CYP1A2PTPN1CA1 | |
| SCHEMBL703196 | 0.77 | TSHR (0.58) | TSHRALDH1A1CYP1A2PTPN1CA1 | |
| SCHEMBL1829408 | 0.77 | TSHR (0.58) | TSHRALDH1A1CYP1A2PTPN1KCNN4 | |
| SCHEMBL10954237 | 0.77 | TSHR (0.58) | TSHRALDH1A1CYP1A2PTPN1KCNN4 | |
| SCHEMBL23525262 | 0.77 | TSHR (0.58) | TSHRALDH1A1CYP1A2PTPN1CA1 | |
| SCHEMBL10885277 | 0.74 | ALDH1A1 (0.55) | TSHRALDH1A1CYP1A2PTPN1CA1 | |
| Trifluoromethylbenzene SCHEMBL6439041 | 0.74 | TSHR (0.82) | TSHRALDH1A1CYP1A2PTPN1CA1 | |
| SCHEMBL13518151 | 0.74 | ALDH1A1 (0.48) | TSHRALDH1A1CYP1A2PTPN1CA1 | |
| Trifluoromethylbenzene SCHEMBL31493124 | 0.73 | TSHR (0.93) | TSHRALDH1A1CYP1A2PTPN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11052076-B2 | Spirocyclic indolines as IL-17 modulators | UCB Biopharma SRL (BE) | 2021-07-06 | — | — | US | disclosed |
| US-20200138797-A1 | Spirocyclic Indolines as IL-17 Modulators | UCB Biopharma SRL (BE) | 2020-05-07 | — | — | US | disclosed |
| EP-3638227-A1 | SPIROCYCLIC INDOLINES AS IL-17 MODULATORS | UCB Biopharma SRL (BE) | 2020-04-22 | — | — | EP | disclosed |
| WO-2018229079-A1 | SPIROCYCLIC INDOLINES AS IL-17 MODULATORS | UCB BIOPHARMA SPRL (BE) | 2018-12-20 | — | — | WO | disclosed |
| US-6852718-B2 | Phenylsulphonylipiperazinyl derivatives as 5-HT receptor ligands | MERCK SHARP & DOHME LTD | 2005-02-08 | — | — | US | disclosed |
| EP-1147084-B1 | PHENYLSULPHONYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME (GB) | 2004-05-19 | — | — | EP | disclosed |
| US-20030181464-A1 | Phenylsulphonylipiperazinyl derivatives as 5-ht receptor ligands | THE INSTITUTE OF CANCER RESEARCH (GB) | 2003-09-25 | — | — | US | disclosed |
| US-6559166-B1 | A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted azetidine, pyrrolidine or piperidine ring are selective antagonists of the human 5-HT2A receptor and are therefore | MERCK SHARP & DOHME LTD. | 2003-05-06 | — | — | US | disclosed |
| EP-1280785-A1 | PHENYLSULPHONYLPIPERAZINYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2003-02-05 | — | — | EP | disclosed |
| US-6316468-B1 | Phenylindole derivatives as 5-HT2A receptor antagonists | MERCK SHARP & DOHME LTD. | 2001-11-13 | — | — | US | disclosed |
| EP-1147084-A1 | PHENYLSULPHONYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2001-10-24 | — | — | EP | disclosed |
| WO-2001074797-A1 | PHENYLSULPHONYLPIPERAZINYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 2001-10-11 | — | — | WO | disclosed |
| WO-2000043362-A1 | PHENYLSULPHONYL DERIVATIVES AS 5-HT RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 2000-07-27 | — | — | WO | disclosed |
| WO-1999011641-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11052076-B2 | Spirocyclic indolines as IL-17 modulators | IL17A, IL2, IL18 | TSHR 1408/4885ALDH1A1 939/4885CYP1A2 339/4885 |
| US-20200138797-A1 | Spirocyclic Indolines as IL-17 Modulators | IL17A, IL2, IL18 | TSHR 1408/4885ALDH1A1 939/4885CYP1A2 339/4885 |
| US-20030181464-A1 | Phenylsulphonylipiperazinyl derivatives as 5-ht receptor ligands | HTR2A, HTR2C, HTR2B | TSHR 21/4885ALDH1A1 1238/4885CYP1A2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.