Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10694786 | 0.78 | HIF1A (0.45) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL164032 | 0.75 | HIF1A (0.67) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL30583946 | 0.75 | HIF1A (0.67) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Phosphine SCHEMBL28255446 | 0.73 | HIF1A (0.64) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL29421497 | 0.73 | HIF1A (0.70) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Iodide SCHEMBL11774415 | 0.72 | HIF1A (0.38) | HIF1AATMALDH1A1 | |
| Bromide SCHEMBL4596472 | 0.72 | HIF1A (0.61) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL28290559 | 0.72 | HIF1A (0.61) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Iodide SCHEMBL297568 | 0.71 | HIF1A (0.67) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Water SCHEMBL3418016 | 0.71 | HIF1A (0.67) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | claimed |
| US-6841205-B1 | Ink-jet printing receiving sheet comprising gelatin and a metal salt | FERRANIA, S.P.A. (IT) | 2005-01-11 | — | — | US | disclosed |
| US-6764727-B1 | INK JET RECEIVING SHEET COMPRISING SUPPORT AND AT LEAST ONE INK RECEIVING LAYER WHICH COMPRISES HIGH BOILING ORGANIC SOLVENT AND NONIONIC SURFACTANT DISPERSED IN HYDROPHILIC BINDER; IMPROVE BLACK DENSITY OF RESULTING IMAGE | FERRANIA S.P.A. (IT) | 2004-07-20 | — | — | US | disclosed |
| EP-1080936-B1 | Receiving sheet for ink-jet printing comprising a surfactant combination | FERRANIA SPA (IT) | 2004-04-28 | — | — | EP | disclosed |
| EP-1080935-B1 | Ink-jet print receiving sheet comprising a high-boiling organic solvent and an non-ionic surfactant | FERRANIA SPA (IT) | 2004-04-14 | — | — | EP | disclosed |
| US-6720043-B1 | SHEET COMPRISING SUPPORT AND INK RECEIVING LAYER COMPRISING BINDER SELECTED FROM GELATIN AND GELATIN DERIVATIVES AND SACCHARIDE SELECTED FROM MONO-, OLIGO-, OR POLY-SACCHARIDES OBTAINED BY ENZYMATIC PROCESSING OF NATURAL POLYSACCHARIDES | FERRANIA, S.P.A. (IT) | 2004-04-13 | — | — | US | disclosed |
| EP-1101625-B1 | Receiving sheet for ink-jet printing comprising a copolymer | FERRANIA SPA (IT) | 2004-04-07 | — | — | EP | disclosed |
| EP-1080934-B1 | Ink-jet printing receiving sheet comprising gelatin and a metal salt | FERRANIA SPA (IT) | 2003-10-29 | — | — | EP | disclosed |
| US-6592953-B1 | Receiving sheet for ink-jet printing comprising a copolymer | FERRANIA, S.P.A. (IT) | 2003-07-15 | — | — | US | disclosed |
| EP-1080937-B1 | Ink-receiving sheet for ink-jet printing comprising a mixture of gelatin and saccharides | FERRANIA SPA (IT) | 2003-03-12 | — | — | EP | disclosed |
| EP-1080935-A2 | Ink-jet print receiving sheet comprising a high-boiling organic solvent and an non-ionic surfactant | FERRANIA S.p.A. (IT) | 2001-03-07 | — | — | EP | disclosed |
| EP-1080934-A1 | Ink-jet printing receiving sheet comprising gelatin and a metal salt | FERRANIA S.p.A. (IT) | 2001-03-07 | — | — | EP | disclosed |
| EP-1080937-A1 | Ink-receiving sheet for ink-jet printing comprising a mixture of gelatin and saccharides | FERRANIA S.p.A. (IT) | 2001-03-07 | — | — | EP | disclosed |
| US-5897940-A | Ink jet transparencies | XEROX CORPORATION (US) | 1999-04-27 | — | — | US | disclosed |
| US-5760809-A | INK JET PRINTING | XEROX CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| US-5714270-A | Multifunctional recording sheets | XEROX CORPORATION (US) | 1998-02-03 | — | — | US | disclosed |
| US-5709976-A | Coated papers | XEROX CORPORATION (US) | 1998-01-20 | — | — | US | disclosed |
| US-5693410-A | Ink jet transparencies | XEROX CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |
| US-5672424-A | Ink jet transparencies | XEROX CORPORATION (US) | 1997-09-30 | — | — | US | disclosed |
| US-5514505-A | SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE | XEROX CORPORATION (US) | 1996-05-07 | — | — | US | disclosed |