Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.34 |
| ▸ | SNCA | P37840 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30583946 | 0.82 | HIF1A (0.67) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL164032 | 0.82 | HIF1A (0.67) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Phosphine SCHEMBL28255446 | 0.80 | HIF1A (0.64) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL29421497 | 0.80 | HIF1A (0.70) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL6299874 | 0.78 | HIF1A (0.38) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL4596472 | 0.78 | HIF1A (0.61) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL28290559 | 0.78 | HIF1A (0.61) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL8053180 | 0.78 | SNCA (0.47) | HIF1AALDH1A1CYP1A2CYP2D6TRAP1 | |
| Fluoride Ion SCHEMBL31171038 | 0.78 | HIF1A (0.67) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL2039214 | 0.78 | HIF1A (0.67) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277910-A1 | 1-Methyl-15-alpha-(1,2-dialkanoyloxyalkyl)androsta-1,4-diene-3-17-diones, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-08-10 | — | — | EP | disclosed |