Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.70 |
| ▸ | XDH | P47989 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15537894 | 0.83 | ALDH1A1 (0.73) | MPOXDHALDH1A1HSD17B10POLB | |
| SCHEMBL2732716 | 0.83 | MPO (0.68) | MPOXDHALDH1A1HSD17B10POLB | |
| SCHEMBL2730975 | 0.83 | MPO (1.00) | MPOXDHALDH1A1HSD17B10POLB | |
| SCHEMBL18708215 | 0.81 | ALDH1A1 (1.00) | MPOXDHALDH1A1HSD17B10HTT | |
| SCHEMBL20289726 | 0.81 | MPO (0.54) | MPOXDHALDH1A1HSD17B10POLB | |
| SCHEMBL2731141 | 0.80 | MPO (1.00) | MPOXDHALDH1A1HSD17B10POLB | |
| SCHEMBL2722783 | 0.79 | MPO (0.63) | MPOXDHALDH1A1HSD17B10POLB | |
| SCHEMBL2731426 | 0.78 | ALDH1A1 (0.74) | MPOXDHALDH1A1HSD17B10HTT | |
| SCHEMBL2730558 | 0.77 | ALDH1A1 (0.73) | MPOXDHALDH1A1HSD17B10HTT | |
| SCHEMBL10288923 | 0.76 | ALDH1A1 (0.79) | MPOXDHALDH1A1HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872727-B1 | Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation | PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2005-03-29 | — | — | US | disclosed |