Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | XDH | P47989 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731426 | 0.86 | ALDH1A1 (0.74) | ALDH1A1HSD17B10MAPK1HTTCA12 | |
| SCHEMBL15538457 | 0.85 | ALDH1A1 (0.73) | ALDH1A1HSD17B10MAPK1HTTMPO | |
| SCHEMBL18708215 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MAPK1HTTCA12 | |
| SCHEMBL10288923 | 0.84 | ALDH1A1 (0.79) | ALDH1A1HSD17B10MAPK1HTTMPO | |
| SCHEMBL15215605 | 0.83 | MPO (0.55) | ALDH1A1HSD17B10MAPK1HTTMPO | |
| Hydrochloric Acid SCHEMBL2732441 | 0.83 | ALDH1A1 (0.77) | ALDH1A1HSD17B10MAPK1HTTMPO | |
| SCHEMBL85957 | 0.78 | IMPDH2 (0.74) | ALDH1A1HSD17B10MAPK1HTTMAPT | |
| SCHEMBL13498727 | 0.77 | ALDH1A1 (0.60) | ALDH1A1HSD17B10MAPK1HTTCA12 | |
| SCHEMBL6300064 | 0.77 | MPO (0.70) | ALDH1A1HSD17B10MAPK1HTTMPO | |
| SCHEMBL2730975 | 0.76 | MPO (1.00) | ALDH1A1HSD17B10MAPK1HTTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632466-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | Emory University (US) | 2013-09-04 | — | — | EP | claimed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | claimed |
| WO-2012058211-A2 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2012-05-03 | — | — | WO | claimed |
| US-9868728-B2 | Quinazoline derivatives, compositions, and uses related thereto | EMORY UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225612-A1 | QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO | NOX4, NOX5, NQO2 | ALDH1A1 458/4885HSD17B10 2477/4885MAPK1 722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.