Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 7/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.51 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CCR4 | P51679 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384306 | 1.00 | FKBP1A (0.56) | FKBP1AITGB1ITGA5PKMALDH1A1 | |
| SCHEMBL630023 | 0.85 | AKR1C3 (0.44) | FKBP1AITGB1ITGA5PKMALDH1A1 | |
| SCHEMBL630983 | 0.85 | CCR4 (0.53) | FKBP1AITGB1ITGA5PKMALDH1A1 | |
| SCHEMBL1381491 | 0.85 | CCR4 (0.53) | FKBP1AITGB1ITGA5PKMALDH1A1 | |
| SCHEMBL630215 | 0.83 | FKBP1A (0.53) | FKBP1AITGB1ITGA5PKMALDH1A1 | |
| SCHEMBL1383786 | 0.83 | FKBP1A (0.53) | FKBP1AITGB1ITGA5PKMALDH1A1 | |
| SCHEMBL630190 | 0.82 | FKBP1A (0.53) | FKBP1AITGB1ITGA5PKMALDH1A1 | |
| SCHEMBL1380441 | 0.82 | FKBP1A (0.53) | FKBP1AITGB1ITGA5PKMALDH1A1 | |
| SCHEMBL1381163 | 0.81 | MMP1 (0.55) | FKBP1AITGB1ITGA5LMNATDP1 | |
| SCHEMBL629854 | 0.81 | MMP1 (0.55) | FKBP1AITGB1ITGA5LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | claimed |
| JP-4812758-B2 | — | — | 2011-11-09 | — | — | JP | claimed |
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | disclosed |