Hydrochloric Acid

Hydrochloric Acid

SCHEMBL6300773

C=CCC1c2ccccc2-c2cccc([Zr+2]c3cccc4c3C(CC=C)c3ccccc3-4)c21.[Cl-].[Cl-]

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.37
KDM4E B2RXH2 1/20 0.31
LMNA P02545 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
GAA P10253 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31
ALOX15 P16050 1/20 0.31
ALOX12 P18054 1/20 0.31
CYP2C19 P33261 1/20 0.31
HTT P42858 1/20 0.31
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
GABRA1 P14867 1/20 0.30
GABRB2 P47870 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6295605 0.84
Hydrochloric Acid SCHEMBL6558645 0.83 HTR2A (0.33) HTR2A
Hydrochloric Acid SCHEMBL6295665 0.82
Hydrochloric Acid SCHEMBL8169416 0.80 HTR2A (0.38) HTR2AKDM4ECA1CA2
SCHEMBL300454 0.80 GABRA1 (0.45) HTR2AKDM4ELMNACYP1A2CYP3A4
Hydrochloric Acid SCHEMBL6720542 0.79 HTR2A (0.37) HTR2ACA1CA2
SCHEMBL10774990 0.78 HTR2A (0.43) HTR2ACA1CA2
SCHEMBL17186645 0.78 HTR2A (0.39) HTR2ACA1CA2
SCHEMBL252162 0.78 HTR2A (0.52) HTR2ACA1CA2
SCHEMBL8612084 0.77 HTR2A (0.38) HTR2ACA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6852660-B2 Solid metallocene catalyst system CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2005-02-08 US claimed
US-20030144436-A1 Coorination catalyst for polyalpha-olefins MITCHELL KENT E (US) 2003-07-31 US claimed
US-6534609-B2 Making by combining an organoaluminoxane and a metallocene having olefinic unsaturated substituent(s) in an aliphatic liquid, prepolymerizing olefin(s) to produce a prepolymerized solid catalyst and separating from the liquid CHEVRON PHILLIPS CHEMICAL COMPANY LP 2003-03-18 US claimed
US-20020177676-A1 Method for making and using a metallocene catalyst system CHEVRON PHILLIPS CHEMICAL COMPANY LP, A DELAWARE LIMITED PARTNERSHIP 2002-11-28 US claimed
WO-2002072641-A1 METHOD FOR MAKING AND USING A METALLOCENE CATALYST SYSTEM CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2002-09-19 WO claimed
WO-1999043724-A1 METHOD FOR POLYMERIZING MONOMERS TO PRODUCE LINEAR, LOW DENSITY POLYMER PHILLIPS PETROLEUM COMPANY (US) 1999-09-02 WO claimed
WO-1998052686-A1 METHOD FOR MAKING AND USING A PREPOLYMERIZED OLEFIN POLYMERIZATION CATALYST PHILLIPS PETROLEUM COMPANY (US) 1998-11-26 WO claimed
EP-0685495-B1 Method for using a supported metallocene catalyst system PHILLIPS PETROLEUM CO (US) 1998-04-08 EP claimed
US-5498581-A OLEFIN POLYMERIZATION PHILLIPS PETROLEUM COMPANY (US) 1996-03-12 US claimed
EP-0685495-A1 Method for making and using a supported metallocene catalyst system PHILLIPS PETROLEUM COMPANY (US) 1995-12-06 EP claimed
US-20050171305-A1 Solid metallocene catalyst system MITCHELL KENT E (US) 2005-08-04 US disclosed
US-6852660-B2 Solid metallocene catalyst system CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2005-02-08 US disclosed
EP-0705851-B9 Catalyst systems and process for producing broad molecular weight distribution polyolefin CONOCOPHILLIPS CO (US) 2004-08-11 EP disclosed
US-6746981-B2 OLEFIN POLYMERIZATION CATALYSTS WITH PRODUCTIVITY WHEN FRESH OF >/= 18,000 GRAMS OF POLYETHYLENE PER GRAM OF CATALYST IN ONE HOUR, AND A SPECIFIC SURFACE AREA OF </= 20 M2/G ALBEMARLE CORPORATION 2004-06-08 US disclosed
US-6730758-B2 ADDITION POLYMERIZATION OF ALPHA-OLEFIN HYDROCARBON IN PRESENCE OF SELF-SUPPORTED VINYLOLEFIN-PREPOLYMERIZED CATALYST ALBEMARLE CORPORATION 2004-05-04 US disclosed
US-5594078-A BRIDGED FLUORENYL METALLOCENE CATALYST PHILLIPS PETROLEUM COMPANY (US) 1997-01-14 US disclosed
US-5534473-A METALLOCENES AND COCATALYST PHILLIPS PETROLEUM COMPANY (US) 1996-07-09 US disclosed
EP-0705851-A2 Catalyst systems and process for producing broad molecular weight distribution polyolefin PHILLIPS PETROLEUM COMPANY (US) 1996-04-10 EP disclosed
US-5498581-A OLEFIN POLYMERIZATION PHILLIPS PETROLEUM COMPANY (US) 1996-03-12 US disclosed
EP-0685495-A1 Method for making and using a supported metallocene catalyst system PHILLIPS PETROLEUM COMPANY (US) 1995-12-06 EP disclosed