Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | OGA | O60502 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469004 | 0.89 | ADRB3 (0.52) | HRH3LMNAP2RY12ADRB3MAPT | |
| SCHEMBL7473044 | 0.89 | ADRB3 (0.52) | HRH3LMNAP2RY12ADRB3MAPT | |
| SCHEMBL7560376 | 0.85 | LMNA (0.56) | HRH3LMNAP2RY12ADRB3MAPT | |
| SCHEMBL7469677 | 0.84 | ADRB1 (0.46) | HRH3LMNAP2RY12ADRB3MAPT | |
| SCHEMBL6303671 | 0.84 | HRH3 (0.48) | HRH3LMNAP2RY12ADRB3MAPT | |
| SCHEMBL6307432 | 0.84 | HRH3 (0.48) | HRH3LMNAP2RY12ADRB3MAPT | |
| SCHEMBL6953322 | 0.83 | HRH3 (0.44) | HRH3LMNAP2RY12ADRB3OGA | |
| SCHEMBL7467963 | 0.83 | LMNA (0.44) | HRH3LMNAP2RY12ADRB3MAPT | |
| SCHEMBL7458989 | 0.82 | HRH3 (0.43) | HRH3LMNAP2RY12ADRB3USP30 | |
| SCHEMBL6301395 | 0.82 | HRH3 (0.53) | HRH3P2RY12USP30OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858629-B1 | Heteroaryloxy propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-02-22 | — | — | US | claimed |
| EP-1214313-B1 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-06-30 | — | — | EP | claimed |
| US-6858629-B1 | Heteroaryloxy propanolamines, preparation method and pharmaceutical compositions containing same | SANOFI-SYNTHELABO (FR) | 2005-02-22 | — | — | US | disclosed |
| EP-1214313-B1 | HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI SYNTHELABO (FR) | 2004-06-30 | — | — | EP | disclosed |