SCHEMBL6302594

SCHEMBL6302594

NC(=O)CCNc1ccccn1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.53
GAA P10253 1/20 0.51
CYP2C19 P33261 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
PKM P14618 1/20 0.50
CXCR4 P61073 1/20 0.49
ITGB3 P05106 2/20 0.48
ITGAV P06756 2/20 0.48
FDPS P14324 1/20 0.47
FABP1 P07148 1/20 0.47
FABP6 P51161 1/20 0.47
HDAC3 O15379 3/20 0.47
HDAC4 P56524 3/20 0.47
HDAC1 Q13547 3/20 0.47
HDAC7 Q8WUI4 3/20 0.47
HDAC2 Q92769 3/20 0.47
HDAC10 Q969S8 3/20 0.47
HDAC11 Q96DB2 3/20 0.47
HDAC8 Q9BY41 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL243759 0.84 ITGB3 (0.63) CYP1A2GAACYP2C19NPC1RAB9A
Hydrochloric Acid SCHEMBL14914649 0.83 ITGB3 (0.61) CYP1A2GAACYP2C19NPC1RAB9A
SCHEMBL13589546 0.83 CYP2C19 (0.56) CYP1A2GAACYP2C19NPC1RAB9A
SCHEMBL27538093 0.83 CYP1A2 (0.53) CYP1A2GAACYP2C19NPC1RAB9A
SCHEMBL2857962 0.82 GAA (0.55) CYP1A2GAACYP2C19NPC1RAB9A
SCHEMBL31483042 0.81 CYP1A2 (0.51) CYP1A2GAACYP2C19NPC1RAB9A
SCHEMBL27823631 0.80 CYP2C19 (0.53) CYP1A2GAACYP2C19NPC1RAB9A
SCHEMBL6781059 0.80 SMN1; SMN2 (0.54) CYP1A2GAACYP2C19NPC1RAB9A
SCHEMBL12818956 0.80 ITGB3 (0.52) CYP1A2GAACYP2C19NPC1RAB9A
SCHEMBL3265804 0.79 CYP1A2 (0.70) CYP1A2GAACYP2C19NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1216866-C bicyclic vitronectin receptor antagonist compounds, process for their preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2005-08-31 CN disclosed
US-6846833-B2 Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same LES LABORATORIES SERVIER (FR) 2005-01-25 US disclosed
EP-1268429-B1 VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME SERVIER LAB (FR) 2004-08-18 EP disclosed
CN-1411444-A Vitronectin receptor antagonist bicyclic compounds, preparation method and compositions containing same SEUWIEL LAB (FR) 2003-04-16 CN disclosed
EP-1268429-A1 VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME Les Laboratoires Servier (FR) 2003-01-02 EP disclosed
WO-2001079172-A1 VITRONECTIN RECEPTOR ANTAGONIST BICYCLIC COMPOUNDS, PREPARATION METHOD AND COMPOSITIONS CONTAINING SAME LES LABORATOIRES SERVIER Departament Brevets/Fontanes (FR) 2001-10-25 WO disclosed