Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630686 | 0.75 | POLB (0.42) | RIPK1MAPTKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL8759 | 0.74 | SLC6A2 (0.56) | RIPK1MAPTKMT2ACYP3A4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3136989 | 0.72 | SLC6A2 (0.54) | RIPK1MAPTKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL5892305 | 0.72 | MAOB (0.44) | KMT2ACYP2C9CYP2C19CYP1A2MAPK1 | |
| SCHEMBL28904890 | 0.71 | MAPT (0.46) | MAPTKMT2ARAB9AHIF1APRSS1 | |
| SCHEMBL6803588 | 0.71 | HDAC3 (0.50) | RIPK1MAPTKMT2AALDH1A1RAB9A | |
| SCHEMBL4040412 | 0.70 | KDM4E (0.54) | MAPTKMT2AALDH1A1RAB9APOLB | |
| SCHEMBL292365 | 0.70 | SMN1; SMN2 (0.54) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27748312 | 0.69 | CYP3A4 (0.42) | RIPK1MAPTKMT2ACYP3A4ALDH1A1 | |
| SCHEMBL28208793 | 0.68 | LMNA (0.51) | MAPTKMT2AALDH1A1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-B1 | FKBP-binding composition and pharmaceutical use thereof | AVENTIS PHARMA INC (US) | 2012-02-22 | — | — | EP | claimed |
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | disclosed |