SCHEMBL630370

SCHEMBL630370

[C]1=CCOOc2ccccc21

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.31
ITGB2 P05107 1/20 0.31
ICAM1 P05362 1/20 0.31
ITGAL P20701 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL276860 0.78 ABCG2 (0.39) ABCG2ITGB2ICAM1ITGAL
SCHEMBL27636969 0.77 ABCG2 (0.37) ABCG2ITGB2ICAM1ITGAL
SCHEMBL450963 0.70 ABCG2 (0.33) ABCG2ITGB2ICAM1ITGAL
SCHEMBL122449 0.67
SCHEMBL315327 0.67 ITGB2 (0.46) ABCG2ITGB2ICAM1ITGAL
SCHEMBL118249 0.62 ABCG2 (0.35) ABCG2ITGB2ICAM1ITGAL
SCHEMBL450542 0.61
SCHEMBL395819 0.60 KDM4E (0.33) ABCG2ITGB2ICAM1ITGAL
SCHEMBL4613477 0.58 MAOA (0.37) ABCG2ITGB2ICAM1ITGAL
SCHEMBL1162560 0.58

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2008540329-A 2008-11-20 JP claimed
EP-1881975-A1 N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-01-30 EP claimed
WO-2006121218-A1 N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-11-16 WO claimed
EP-3080124-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS Takeda Pharmaceutical Company Limited (JP) 2016-10-19 EP disclosed
WO-2015088045-A1 PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS TLR INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-06-18 WO disclosed
EP-2838891-A1 AROMATIC RING COMPOUND Takeda Pharmaceutical Company Limited (JP) 2015-02-25 EP disclosed
EP-2814466-A1 TABLET Takeda Pharmaceutical Company Limited (JP) 2014-12-24 EP disclosed
EP-2802571-A1 BENZIMIDAZOLE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS Takeda Pharmaceutical Company Limited (JP) 2014-11-19 EP disclosed
WO-2014168262-A1 KINASE INHIBITORS CONTAINING CYCLOPROPANE SKELETON D.D.P. CORPORATION (JP) 2014-10-16 WO disclosed
EP-2649062-A1 BICYCLIC COMPOUNDS AS INHIBITORS OF ACETYL-COA CARBOXYLASE (ACC) Takeda Pharmaceutical Company Limited (JP) 2013-10-16 EP disclosed
WO-2013125732-A1 AROMATIC RING COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-08-29 WO disclosed
EP-1881975-A1 N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-01-30 EP disclosed
WO-2007097470-A2 FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-30 WO disclosed
WO-2007094513-A2 CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-08-23 WO disclosed
WO-2007077961-A2 FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-07-12 WO disclosed
WO-2007064045-A1 FUSED HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-06-07 WO disclosed
WO-2007018314-A2 THERAPEUTIC AGENT FOR DIABETES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-02-15 WO disclosed
WO-2006121218-A1 N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-11-16 WO disclosed
EP-1631294-A1 A METHOD OF TREATING AN ANXIETY DISORDER KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-03-08 EP disclosed
WO-2004108137-A1 A METHOD OF TREATING AN ANXIETY DISORDER KYOWA HAKKO KOGYO CO., LTD. (JP) 2004-12-16 WO disclosed