Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2577064 | 0.81 | TSHR (0.51) | GRM5SMN1; SMN2L3MBTL1NPC1MAPT | |
| SCHEMBL5215858 | 0.77 | GRM5 (0.58) | METAP1GRM5SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL630468 | 0.76 | MAPT (0.53) | L3MBTL1NPC1MAPTMAPK1RAB9A | |
| SCHEMBL6014884 | 0.74 | CYP2A6 (0.47) | METAP1GRM5SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL5215879 | 0.71 | GRM5 (0.54) | METAP1GRM5SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL4701486 | 0.69 | NPC1 (0.67) | GRM5NPC1MAPTMAPK1RAB9A | |
| SCHEMBL1459767 | 0.69 | KDM4E (0.50) | METAP1SMN1; SMN2L3MBTL1NPC1MAPT | |
| SCHEMBL15075728 | 0.67 | NPC1 (0.62) | METAP1GRM5SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL13860632 | 0.64 | RAB9A (0.59) | METAP1GRM5SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL31175944 | 0.63 | CCR1 (0.55) | METAP1GRM5SMN1; SMN2L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534680-B1 | PRENYLATION INHIBITORS AND METHODS OF THEIR SYNTHESIS AND USE | PHARMACO INVESTMENTS INC (US) | 2012-02-22 | — | — | EP | disclosed |
| US-7501446-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20070149549-A1 | 3-(Pyrid-3-yl)-5-(thiophen-2-yl)-pyrazoles; prenyl-protein transferase inhibitors | PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC | 2007-06-28 | — | — | US | disclosed |
| US-7166619-B2 | Prenylation inhibitors and methods of their synthesis and use | PPD DISCOVERY , INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-20040116425-A1 | Prenylation inhibitors and methods of their synthesis and use | X-CHEM, INC. | 2004-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149549-A1 | 3-(Pyrid-3-yl)-5-(thiophen-2-yl)-pyrazoles; prenyl-protein transferase inhibitors | FNTA, PTAR1, ZMPSTE24 | METAP1 1029/4885GRM5 4327/4885SMN1; SMN2 4110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.