Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 2/20 | 0.39 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419414 | 0.76 | CES1 (0.39) | KCNA3CES1HSD17B10 | |
| SCHEMBL289277 | 0.72 | ACHE (0.39) | KCNA3F2RL1CES1 | |
| SCHEMBL12279309 | 0.72 | HSD17B10 (0.38) | KCNA3CES1HSD17B10 | |
| SCHEMBL20111022 | 0.72 | HSD17B10 (0.38) | KCNA3CES1HSD17B10 | |
| SCHEMBL18329488 | 0.72 | SMN1; SMN2 (0.42) | KCNA3F2RL1CES1 | |
| SCHEMBL13725473 | 0.69 | KCNA3 (0.39) | KCNA3HSD17B10 | |
| SCHEMBL19584837 | 0.69 | F2RL1 (0.43) | KCNA3F2RL1CES1 | |
| SCHEMBL20793964 | 0.69 | SMN1; SMN2 (0.53) | KCNA3CES1HSD17B10 | |
| SCHEMBL2094794 | 0.68 | ALDH1A1 (0.39) | KCNA3CES1 | |
| SCHEMBL20793965 | 0.65 | SMN1; SMN2 (0.35) | KCNA3CES1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967201-B1 | for increasing activation of the 5-HT2C receptor in mammals; treatment of depression, obesity, bulimia, premenstrual syndrome, alcoholism, tobacco abuse, panic disorder | ELI LILLY AND COMPANY (US) | 2005-11-22 | — | — | US | disclosed |
| EP-1204654-B1 | BENZOFURYLPIPERAZINES: 5-HT2C SEROTONIN RECEPTOR AGONISTS | LILLY CO ELI (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-1204654-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009111-A1 | BENZOFURYLPIPERAZINES AND BENZOFURYLHOMOPIPERAZINES: SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |