Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31191648 | 0.80 | KDM4E (0.35) | KCNA3TSHRKDM4EALDH1A1MAPK1 | |
| SCHEMBL719413 | 0.80 | KDM4E (0.35) | KCNA3TSHRKDM4EALDH1A1MAPK1 | |
| SCHEMBL16345128 | 0.77 | KCNA3 (0.38) | KCNA3TSHRKDM4EALDH1A1MAPK1 | |
| SCHEMBL17321059 | 0.77 | KCNA3 (0.36) | KCNA3TSHRKDM4EALDH1A1MAPK1 | |
| SCHEMBL3873319 | 0.74 | ALDH1A1 (0.42) | KCNA3TSHRKDM4EALDH1A1MAPK1 | |
| SCHEMBL5986722 | 0.73 | KCNA3 (0.36) | KCNA3TSHRKDM4EALDH1A1MAPK1 | |
| SCHEMBL6305348 | 0.69 | KCNA3 (0.39) | KCNA3HSD17B10 | |
| SCHEMBL289277 | 0.68 | ACHE (0.39) | KCNA3ALDH1A1 | |
| SCHEMBL30395048 | 0.68 | ACHE (0.39) | KCNA3ALDH1A1 | |
| SCHEMBL11539348 | 0.67 | PTPN1 (0.61) | KCNA3TSHRKDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2702043-A1 | INHIBITORS OF INDUCIBLE FORM OF 6-PHOSPHOFRUCTOSE-2-KINASE | Exelixis, Inc. (US) | 2014-03-05 | — | — | EP | disclosed |
| WO-2012149528-A1 | INHIBITORS OF INDUCIBLE FORM OF 6-PHOSPHOFRUCTOSE-2-KINASE | EXELIXIS, INC. (US) | 2012-11-01 | — | — | WO | disclosed |