Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554374 | 0.84 | HPGD (0.45) | HPGDKMT2AHTTL3MBTL1MEN1 | |
| SCHEMBL15981916 | 0.81 | HPGD (0.52) | HPGDKMT2AL3MBTL1DYRK1ALMNA | |
| SCHEMBL26820 | 0.79 | HPGD (0.54) | HPGDDAOHCAR2HCAR3 | |
| SCHEMBL42514 | 0.77 | HPGD (0.52) | HPGDKMT2ADYRK1ALMNADAO | |
| SCHEMBL5013388 | 0.77 | HPGD (0.52) | HPGDDYRK1ALMNADAOHCAR2 | |
| Hydrochloric Acid SCHEMBL27727584 | 0.77 | HPGD (0.52) | HPGDDAOHCAR2HCAR3 | |
| SCHEMBL25449 | 0.77 | MAPK1 (0.57) | HPGDKMT2AL3MBTL1MEN1NPSR1 | |
| SCHEMBL18680106 | 0.77 | HPGD (0.49) | HPGDKMT2AHTTL3MBTL1MEN1 | |
| SCHEMBL5010480 | 0.75 | NOTUM (0.43) | HPGDKMT2AMEN1ALDH1A1ERN1 | |
| SCHEMBL27727586 | 0.75 | HPGD (0.46) | HPGDKMT2AHTTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903131-B2 | 3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists | SCHERING CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| US-6878709-B2 | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists | SCHERING CORPORATION (US) | 2005-04-12 | — | — | US | disclosed |
| EP-1461321-A1 | 3,4-DI-SUBSTITUTED PYRIDAZINEDIONES AS CXC CHEMOKINE RECEPTOR ANTAGONISTS | Schering Corporation (US) | 2004-09-29 | — | — | EP | disclosed |
| US-20040063709-A1 | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists | SCHERING CORPORATION | 2004-04-01 | — | — | US | disclosed |
| US-20040034229-A1 | 3,4-Di-substituted maleimide compounds as CXC chemokine receptor antagonists | SCHERING CORPORATION | 2004-02-19 | — | — | US | disclosed |
| WO-2003057676-A1 | 3,4-DI-SUBSTITUTED PYRIDAZINEDIONES AS CXC CHEMOKINE RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034229-A1 | 3,4-Di-substituted maleimide compounds as CXC chemokine receptor antagonists | CXCR1, CCR1, CCL2 | HPGD 404/4885KMT2A 4497/4885HTT 4850/4885 |
| US-20040063709-A1 | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists | CXCR1, CCR1, ACKR3 | HPGD 175/4885KMT2A 4671/4885HTT 4862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.