Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15981916 | 0.81 | HPGD (0.52) | HPGDLMNAGAADYRK1AMAPT | |
| SCHEMBL14688254 | 0.80 | HPGD (0.46) | HPGDLMNAMAPTPOLBALDH1A1 | |
| SCHEMBL26820 | 0.79 | HPGD (0.54) | HPGDHCAR2DAOHCAR3 | |
| SCHEMBL42514 | 0.77 | HPGD (0.52) | HPGDLMNAGAADYRK1AMAPT | |
| SCHEMBL5013388 | 0.77 | HPGD (0.52) | HPGDLMNADYRK1AMAPTHCAR2 | |
| Hydrochloric Acid SCHEMBL27727584 | 0.77 | HPGD (0.52) | HPGDHCAR2DAOHCAR3 | |
| SCHEMBL6305513 | 0.77 | HPGD (0.49) | HPGDLMNAGAADYRK1AHCAR2 | |
| SCHEMBL25449 | 0.77 | MAPK1 (0.57) | HPGDGAADYRK1AMAPTPOLB | |
| SCHEMBL17928435 | 0.74 | HPGD (0.49) | HPGDLMNADYRK1AMAPTPOLB | |
| SCHEMBL14620257 | 0.73 | HPGD (0.49) | HPGDDYRK1AMAPTHCAR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018174-A1 | QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION | VENTANA MED SYST INC (US) | 2024-01-18 | — | — | US | disclosed |
| US-11860167-B2 | Application of click chemistry for signal amplification in IHC and ISH assays | VENTANA MEDICAL SYSTEMS, INC. (US) | 2024-01-02 | — | — | US | disclosed |
| US-11780863-B2 | Quinone methide analog signal amplification | VENTANA MEDICAL SYSTEMS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20170089911-A1 | QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION | VENTANA MEDICAL SYSTEMS, INC. | 2017-03-30 | — | — | US | disclosed |
| US-20170089911-A1 | QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION | VENTANA MEDICAL SYSTEMS, INC. | 2017-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780863-B2 | Quinone methide analog signal amplification | NQO2, SQOR, MRM1 | HPGD 634/4885LMNA 3732/4885GAA 231/4885 |
| US-11860167-B2 | Application of click chemistry for signal amplification in IHC and ISH assays | MKI67, TIE1, ALK | HPGD 1604/4885LMNA 3260/4885GAA 4441/4885 |
| US-20240018174-A1 | QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION | NQO2, SQOR, MRM1 | HPGD 634/4885LMNA 3732/4885GAA 231/4885 |
| US-20170089911-A1 | QUINONE METHIDE ANALOG SIGNAL AMPLIFICATION | NQO2, SQOR, MRM1 | HPGD 634/4885LMNA 3732/4885GAA 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.