Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 2/20 | 0.31 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6301321 | 0.85 | LTB4R (0.32) | LTB4RLTB4R2BRD4ADRB2ADRB1 | |
| SCHEMBL6700648 | 0.84 | LTB4R (0.36) | LTB4RLTB4R2BRD4ADRB2ADRB1 | |
| Bromide SCHEMBL6300825 | 0.84 | LTB4R (0.35) | LTB4RLTB4R2BRD4ADRB2ADRB1 | |
| SCHEMBL6300176 | 0.83 | BRD4 (0.36) | LTB4RLTB4R2BRD4ADRB2ADRB1 | |
| SCHEMBL6300888 | 0.82 | SMN1; SMN2 (0.32) | MAPTLTB4RLTB4R2 | |
| SCHEMBL6306132 | 0.82 | LTB4R (0.47) | LTB4RLTB4R2BRD4ADRB2ADRB1 | |
| SCHEMBL6300110 | 0.82 | LTB4R (0.35) | CYP1A2CYP2C19CYP2C9MEN1KMT2A | |
| SCHEMBL6299367 | 0.82 | LTB4R (0.35) | CYP2C19LTB4RLTB4R2BRD4ADRB2 | |
| SCHEMBL6306125 | 0.82 | LTB4R (0.47) | LTB4RLTB4R2BRD4ADRB2ADRB1 | |
| SCHEMBL6299673 | 0.81 | LTB4R (0.39) | LTB4RLTB4R2BRD4ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6943183-B2 | 5-substituted tetralones as inhibitors of ras farnesyl transferase | PFIZER INC (US) | 2005-09-13 | — | — | US | disclosed |
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | WARNER-LAMBERT COMPANY | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044057-A1 | 5- substituted tetralones as inhibitors of ras farnesyl trransferase | PTAR1, FNTA, GGPS1 | CYP1A2 893/4885MAPT 3013/4885CYP2C19 2426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.