Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | F11 | P03951 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394256 | 0.90 | EGFR (0.55) | GHSRALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL6307779 | 0.90 | EGFR (0.57) | ALDH1A1MAPTHPGDMAPK1RXFP1 | |
| SCHEMBL6308188 | 0.89 | GHSR (0.54) | GHSRMAPTEGFRABCC1F11 | |
| SCHEMBL6308112 | 0.89 | KMT2A (0.50) | GHSRRXFP1EGFRPOLBSMN1; SMN2 | |
| SCHEMBL6306926 | 0.88 | MEN1 (0.50) | ALDH1A1MAPTHPGDMAPK1RXFP1 | |
| SCHEMBL6307622 | 0.88 | F11 (0.59) | GHSRALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL6314165 | 0.88 | GHSR (0.61) | GHSRMAPTMAPK1RXFP1EGFR | |
| SCHEMBL6309608 | 0.87 | GHSR (0.43) | GHSRALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL6306850 | 0.84 | F11 (0.59) | ALDH1A1MAPTHPGDMAPK1RXFP1 | |
| SCHEMBL6314931 | 0.84 | F11 (0.52) | ALDH1A1MAPTHPGDMAPK1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |