Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | CASR | P41180 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6394256 | 0.98 | EGFR (0.55) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL6308112 | 0.94 | KMT2A (0.50) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL6306926 | 0.94 | MEN1 (0.50) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL6307036 | 0.90 | GHSR (0.55) | EGFRPOLBRXFP1ALDH1A1MEN1 | |
| SCHEMBL6313940 | 0.89 | EGFR (0.56) | EGFRPOLBRXFP1MEN1KMT2A | |
| SCHEMBL6308923 | 0.87 | MAPT (0.46) | EGFRJAK2JAK1TYK2JAK3 | |
| SCHEMBL6306850 | 0.87 | F11 (0.59) | POLBRXFP1ALDH1A1MEN1KMT2A | |
| SCHEMBL6313293 | 0.87 | CASR (0.52) | EGFRCASRPOLB | |
| SCHEMBL6314931 | 0.87 | F11 (0.52) | POLBRXFP1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6306955 | 0.86 | EGFR (0.72) | EGFRJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |