Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | MC4R | P32245 | 4/20 | 0.41 |
| ▸ | MC5R | P33032 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 3/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | MC1R | Q01726 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6556276 | 0.80 | EPHX1 (0.48) | CYP2A6SLC1A3SLC1A2SLC1A1SIGMAR1 | |
| SCHEMBL10622532 | 0.80 | EPHX1 (0.48) | CYP2A6SLC1A3SLC1A2SLC1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL5711578 | 0.78 | EPHX1 (0.47) | CYP2A6SLC1A3SLC1A2SLC1A1SIGMAR1 | |
| SCHEMBL11748582 | 0.78 | HTR2A (0.67) | HTR2AHTR2CHTR2BTACR1MC4R | |
| SCHEMBL7342778 | 0.78 | HTR2A (0.57) | HTR2AHTR2CHTR2BTACR1MC4R | |
| SCHEMBL14387258 | 0.76 | HTR2A (0.55) | HTR2AHTR2CHTR2BTACR1MC4R | |
| SCHEMBL5704618 | 0.75 | ESR1 (0.53) | — | |
| SCHEMBL9543643 | 0.75 | ESR1 (0.37) | ADRB2 | |
| SCHEMBL17407614 | 0.75 | HTR2A (0.73) | HTR2AHTR2CHTR2BTACR1MC4R | |
| SCHEMBL5704643 | 0.73 | SLC6A4 (0.52) | HTR2AHTR2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599178-A1 | MEANS AND METHOD FOR DYEING KERATIN FIBRES | Wella Aktiengesellschaft (DE) | 2005-11-30 | — | — | EP | disclosed |
| US-6852744-B2 | Pyrrolidine derivatives and their use as chymase inhibitor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2005-02-08 | — | — | US | disclosed |
| WO-2004078151-A1 | MEANS AND METHOD FOR DYEING KERATIN FIBRES | WELLA AKTIENGESELLSCHAFT (DE) | 2004-09-16 | — | — | WO | disclosed |
| US-20040102384-A1 | Pyrrolidine derivatives and their use as chymase inhibitor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
| EP-1313730-A1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS CHYMASE INHIBITOR | Dainippon Pharmaceutical Co., Ltd. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018378-A1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS CHYMASE INHIBITOR | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102384-A1 | Pyrrolidine derivatives and their use as chymase inhibitor | CMA1, CTRL, TPSD1 | HTR2A 2892/4885HTR2C 2227/4885HTR2B 1908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.