SCHEMBL9543643

SCHEMBL9543643

Nc1ccc(CC(N)C(O)C(F)(F)F)cc1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
GFER P55789 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
GRB2 P62993 1/20 0.36
LOXL2 Q9Y4K0 1/20 0.35
CSNK1E P49674 1/20 0.35
MAOB P27338 4/20 0.34
FDPS P14324 1/20 0.34
ADRB2 P07550 4/20 0.34
TAAR1 Q96RJ0 2/20 0.33
PTPN1 P18031 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5704618 0.85 ESR1 (0.53) ESR1ESR2TAAR1
SCHEMBL5704643 0.84 SLC6A4 (0.52) ESR1ESR2ALDH1A1CYP3A4TAAR1
SCHEMBL10622532 0.83 EPHX1 (0.48) CSNK1ETAAR1
SCHEMBL6556276 0.83 EPHX1 (0.48) CSNK1ETAAR1
Hydrochloric Acid SCHEMBL5711578 0.81 EPHX1 (0.47) CSNK1ETAAR1
SCHEMBL6307263 0.75 HTR2A (0.54) ADRB2
SCHEMBL10876390 0.73 GFER (0.48) GFERALDH1A1CYP3A4TSHRTDP1
SCHEMBL23586172 0.71 ALDH1A1 (0.50) GFERALDH1A1CYP3A4TSHRTDP1
SCHEMBL11413099 0.70 SLC7A5 (0.46) TDP1GRB2
SCHEMBL4693256 0.70 GFER (0.44) GFERALDH1A1CYP3A4TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993008211-A1 TRIPEPTIDE DERIVATIVE ANTI-INFLAMMATORY AGENTS THE PROCTER & GAMBLE COMPANY (US) 1993-04-29 WO disclosed