SCHEMBL6308147

SCHEMBL6308147

CS(=O)(=O)c1ccc(-c2coc(=O)n2-c2ccc(Cl)c(Cl)c2)cc1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 20/20 0.78
PTGS1 P23219 19/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8726248 0.90 PTGS2 (0.72) PTGS2PTGS1
SCHEMBL13943912 0.90 PTGS2 (0.74) PTGS2PTGS1
SCHEMBL8720980 0.89 PTGS2 (0.74) PTGS2PTGS1
SCHEMBL6300780 0.88 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL4575742 0.86 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL6300839 0.85 PTGS2 (0.78) PTGS2PTGS1
SCHEMBL13944766 0.83 PTGS2 (0.64) PTGS2PTGS1
SCHEMBL6722672 0.82 PTGS2 (0.60) PTGS2PTGS1
SCHEMBL6733675 0.82 PTGS2 (0.60) PTGS2PTGS1
SCHEMBL8398364 0.82 PTGS2 (1.00) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6869968-B1 Such as 3-(4-fluorophenyl)-4-(4-methysulphonylphenyl)-2-(3H)-oxazolone; for treating colorectal cancer, fevers, and inflammation ALLMIRALL PRODESFARMA S.A. (ES) 2005-03-22 US claimed
US-5866596-A DRUGS WITH ANTIINFLAMMATORY AND ANALGESIC PROPERTIES. LABORATORIES UPSA (FR) 1999-02-02 US claimed
WO-1998011080-A1 NOVEL 3,4-DIARYLOXAZOLONE DERIVATIVES, METHODS OF PREPARATION AND THERAPEUTIC USES THEREOF LABORATOIRES UPSA (FR) 1998-03-19 WO claimed
US-5866596-A DRUGS WITH ANTIINFLAMMATORY AND ANALGESIC PROPERTIES. LABORATORIES UPSA (FR) 1999-02-02 US disclosed
WO-1998011080-A1 NOVEL 3,4-DIARYLOXAZOLONE DERIVATIVES, METHODS OF PREPARATION AND THERAPEUTIC USES THEREOF LABORATOIRES UPSA (FR) 1998-03-19 WO disclosed