SCHEMBL4575742

SCHEMBL4575742

CS(=O)(=O)c1ccc(-c2coc(=O)n2-c2ccc(Cl)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 19/20 1.00
PTGS1 P23219 16/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8398364 0.88 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL6302878 0.86 PTGS2 (0.78) PTGS2PTGS1
SCHEMBL4576392 0.86 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL4577762 0.86 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8397305 0.86 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL6308147 0.86 PTGS2 (0.78) PTGS2PTGS1
SCHEMBL6300839 0.86 PTGS2 (0.78) PTGS2PTGS1
SCHEMBL8720980 0.85 PTGS2 (0.74) PTGS2PTGS1
SCHEMBL8073215 0.84 PTGS2 (1.00) PTGS2PTGS1
SCHEMBL8726248 0.84 PTGS2 (0.72) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1414526-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER Pharmacia Corporation (US) 2004-05-06 EP claimed
WO-2002085459-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER PHARMACIA CORPORATION (US) 2002-10-31 WO claimed
US-20020103141-A1 Antiangiogenic combination therapy for the treatment of cancer PHARMACIA CORPORATION 2002-08-01 US claimed
US-5866596-A DRUGS WITH ANTIINFLAMMATORY AND ANALGESIC PROPERTIES. LABORATORIES UPSA (FR) 1999-02-02 US claimed
US-20260027079-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF EPM IP INC (US) 2026-01-29 US disclosed
CN-118831076-A Cannabinoid acid ester compositions and uses thereof EPM (IP)公司 2024-10-25 CN disclosed
CN-113840598-B Cannabinoid acid ester compositions and uses thereof EPM (IP)公司 2024-07-05 CN disclosed
US-20230202964-A1 CANNABIGEROLIC ACID (CDGA) DERIVATIVES AND USES THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2023-06-29 US disclosed
US-20230192588-A1 CANNABIDIOLIC ACID (CBDA) DERIVATIVES AND USES THEREOF YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2023-06-22 US disclosed
EP-4161900-A1 CANNABIDIOLIC ACID (CBDA) DERIVATIVES AND USES THEREOF Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. (IL) 2023-04-12 EP disclosed
US-20220151972-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF EPM (IP), INC. 2022-05-19 US disclosed
CN-113840598-A Cannabinoid acid ester compositions and uses thereof EPM (IP)公司 2021-12-24 CN disclosed
WO-2003020268-A1 METHOD FOR THE TREATMENT AND PREVENTION OF CACHEXIA WASHINGTON UNIVERSITY (US) 2003-03-13 WO disclosed
WO-2003015608-A2 COMBINATION THERAPY FOR THE TREATMENT OF CANCER SUGEN, INC. (US) 2003-02-27 WO disclosed
WO-2002085459-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER PHARMACIA CORPORATION (US) 2002-10-31 WO disclosed
US-20020128267-A1 Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders PHARMACIA CORPORATION 2002-09-12 US disclosed
US-20020103141-A1 Antiangiogenic combination therapy for the treatment of cancer PHARMACIA CORPORATION 2002-08-01 US disclosed
EP-1189628-A1 COMBINATION OF TUMOR NECROSIS FACTOR (TNF) ANTAGONISTS AND COX-2 INHIBITORS FOR THE TREATMENT OF INFLAMMATION Pharmacia Corporation (US) 2002-03-27 EP disclosed
WO-2001000229-A1 COMBINATION OF TUMORS NECROCIS FACTOR (TNF) ANTAGONISTS AND COX-2 INHIBITORS FOR THE TREATMENT OF INFLAMMATION PHARMACIA CORPORATION (US) 2001-01-04 WO disclosed
US-5866596-A DRUGS WITH ANTIINFLAMMATORY AND ANALGESIC PROPERTIES. LABORATORIES UPSA (FR) 1999-02-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192588-A1 CANNABIDIOLIC ACID (CBDA) DERIVATIVES AND USES THEREOF CNR2, CNR1, GPR18 PTGS2 1908/4885PTGS1 1885/4885
US-20020103141-A1 Antiangiogenic combination therapy for the treatment of cancer TOP2A, TOP2B, TOP1 PTGS2 4/4885PTGS1 6/4885
US-20220151972-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF CNR2, CNR1, FAAH PTGS2 2331/4885PTGS1 2318/4885
US-20260027079-A1 CANNABINOID ACID ESTER COMPOSITIONS AND USES THEREOF CNR2, CNR1, FAAH PTGS2 2555/4885PTGS1 2010/4885
US-20020128267-A1 Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders PTGS2, PTGES2, PTGS1 PTGS2 1/4885PTGS1 3/4885
US-20230202964-A1 CANNABIGEROLIC ACID (CDGA) DERIVATIVES AND USES THEREOF CNR2, CNR1, GPR18 PTGS2 411/4885PTGS1 495/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.