Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6309009 | 0.91 | SMN1; SMN2 (0.51) | F11SMN1; SMN2LMNARXFP1ALDH1A1 | |
| SCHEMBL6308495 | 0.90 | F11 (0.59) | F11SMN1; SMN2LMNARXFP1ALDH1A1 | |
| SCHEMBL6308920 | 0.89 | EGFR (0.51) | F11SMN1; SMN2LMNAMAPTPOLB | |
| SCHEMBL6307014 | 0.88 | F11 (0.67) | F11SMN1; SMN2LMNARXFP1ALDH1A1 | |
| SCHEMBL6314616 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAALDH1A1MAPK1TSHR | |
| SCHEMBL6306921 | 0.87 | F11 (0.63) | F11SMN1; SMN2LMNARXFP1ALDH1A1 | |
| SCHEMBL7549056 | 0.87 | F11 (0.59) | F11SMN1; SMN2LMNARXFP1ALDH1A1 | |
| SCHEMBL6308394 | 0.86 | F11 (0.65) | F11SMN1; SMN2LMNARXFP1ALDH1A1 | |
| SCHEMBL6306810 | 0.86 | F11 (0.62) | F11SMN1; SMN2LMNARXFP1ALDH1A1 | |
| SCHEMBL6308567 | 0.85 | F11 (0.64) | F11SMN1; SMN2LMNARXFP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |