Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314101 | 0.89 | POLB (0.62) | SMN1; SMN2LMNAPOLBABCC1KDM4E | |
| SCHEMBL6309009 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAPOLBABCC1KDM4E | |
| SCHEMBL6308236 | 0.87 | F11 (0.56) | SMN1; SMN2LMNAPOLBKDM4ECYP1A2 | |
| SCHEMBL6314294 | 0.86 | EGFR (0.59) | SMN1; SMN2LMNAPOLBABCC1KDM4E | |
| SCHEMBL6308920 | 0.86 | EGFR (0.51) | SMN1; SMN2LMNAPOLBABCC1MAPT | |
| SCHEMBL6307999 | 0.83 | ALDH1A1 (0.69) | SMN1; SMN2LMNAPOLBKDM4ECYP1A2 | |
| SCHEMBL6309193 | 0.83 | F11 (0.62) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL6309029 | 0.82 | CASR (0.68) | SMN1; SMN2LMNAALDH1A1MAPTTSHR | |
| SCHEMBL6313886 | 0.82 | ALDH1A1 (0.57) | SMN1; SMN2LMNAPOLBKDM4EALDH1A1 | |
| SCHEMBL6309730 | 0.82 | ALDH1A1 (0.59) | SMN1; SMN2LMNAPOLBKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |