Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | RORA | P35398 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | RORB | Q92753 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6307536 | 0.89 | CASR (0.52) | CASREGFRPGRRORARORC | |
| SCHEMBL6313246 | 0.89 | CASR (0.58) | CASREGFRGHSR | |
| SCHEMBL6306196 | 0.88 | CASR (0.53) | CASRRXRATDP1 | |
| SCHEMBL6307779 | 0.87 | EGFR (0.57) | CASREGFRPOLB | |
| SCHEMBL6307828 | 0.87 | F11 (0.52) | GHSRRXRATDP1 | |
| SCHEMBL6394256 | 0.85 | EGFR (0.55) | CASREGFRGHSRPOLB | |
| SCHEMBL6308112 | 0.83 | KMT2A (0.50) | CASREGFRGHSRPOLB | |
| SCHEMBL6306926 | 0.83 | MEN1 (0.50) | CASREGFRPOLB | |
| SCHEMBL6308902 | 0.82 | EGFR (0.64) | CASREGFR | |
| SCHEMBL6307036 | 0.82 | GHSR (0.55) | EGFRGHSRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |