Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.51 |
| ▸ | RXRA | P19793 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313293 | 0.88 | CASR (0.52) | CASRTDP1RXRA | |
| SCHEMBL6308910 | 0.87 | CASR (0.53) | CASRTSHRTDP1RXRAALDH1A1 | |
| SCHEMBL6313246 | 0.86 | CASR (0.58) | CASRSMN1; SMN2TP53MAPTMEN1 | |
| SCHEMBL6308902 | 0.86 | EGFR (0.64) | CASRSMN1; SMN2TP53MAPTMEN1 | |
| SCHEMBL6307828 | 0.84 | F11 (0.52) | TSHRTDP1RXRAALDH1A1SMN1; SMN2 | |
| SCHEMBL6309029 | 0.84 | CASR (0.68) | CASRTSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5921199 | 0.83 | CASR (0.75) | CASRSMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL6314431 | 0.82 | MEN1 (0.67) | CASRALDH1A1TP53MAPTGAA | |
| SCHEMBL6314002 | 0.82 | CASR (0.65) | CASRTSHRALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL6306167 | 0.80 | KMT2A (0.63) | CASRTSHRALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |