Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25028208 | 0.90 | CYP2A6 (0.56) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL3789614 | 0.81 | CYP2A6 (0.58) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL368354 | 0.79 | CYP2A6 (0.56) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL8290973 | 0.79 | CYP2A6 (0.60) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL25030309 | 0.79 | ALDH1A1 (0.54) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL9347766 | 0.78 | CYP2A6 (0.55) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL9347729 | 0.78 | CYP2A6 (0.55) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL25030035 | 0.78 | CYP2A6 (0.50) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL25029575 | 0.78 | CYP2A6 (0.50) | CYP2A6SLC6A4SMN1; SMN2ALDH1A1IDO1 | |
| SCHEMBL81236 | 0.77 | CYP2A6 (0.58) | CYP2A6SMN1; SMN2ALDH1A1IDO1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844344-B2 | Benzofuran derivatives | ELI LILLY AND COMPANY (US) | 2005-01-18 | — | — | US | disclosed |
| US-20030232833-A1 | Benzofuran derivatives | ELI LILLY AND COMPANY | 2003-12-18 | — | — | US | disclosed |
| EP-1246822-A1 | BENZOFURAN DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001046177-A1 | BENZOFURAN DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232833-A1 | Benzofuran derivatives | BRD1, BPTF, HTR1F | CYP2A6 533/4885SLC6A4 227/4885SMN1; SMN2 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.