Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665113 | 0.84 | CA1 (0.49) | ESR1ESR2NPC1RAB9APTGS2 | |
| SCHEMBL13588380 | 0.83 | PIN1 (0.54) | ESR1ESR2NPC1RAB9ACYP1A2 | |
| SCHEMBL6373445 | 0.83 | ESR1 (0.51) | ESR1ESR2NPC1RAB9APTGS2 | |
| SCHEMBL1675397 | 0.79 | RXRA (0.49) | ESR1ESR2NPC1RAB9ACYP1A2 | |
| SCHEMBL6374551 | 0.78 | ESR1 (0.56) | ESR1ESR2RAB9A | |
| SCHEMBL4221887 | 0.78 | MEN1 (0.55) | ESR1ESR2RAB9APTGS2 | |
| SCHEMBL5374898 | 0.78 | MAOB (0.52) | ESR1ESR2NPC1RAB9APTGS2 | |
| SCHEMBL6374522 | 0.77 | ESR1 (0.59) | ESR1ESR2NPC1RAB9ACYP1A2 | |
| SCHEMBL1675512 | 0.76 | ALDH1A1 (0.47) | NPC1RAB9ACYP19A1 | |
| SCHEMBL3930795 | 0.75 | ESR1 (1.00) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272786-A1 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | WYETH (US) | 2005-12-08 | — | — | US | disclosed |
| US-6960607-B2 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | WYETH (US) | 2005-11-01 | — | — | US | disclosed |
| US-20030171412-A1 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | WYETH | 2003-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171412-A1 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | ESR1, ESR2, ESRRA | ESR1 1/4885ESR2 2/4885NPC1 1157/4885 |
| US-20050272786-A1 | Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents | ESR1, ESRRA, ESR2 | ESR1 1/4885ESR2 3/4885NPC1 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.