Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30797718 | 0.84 | SLC6A4 (0.46) | HTR1ADRD2DRD3KDM4EMEN1 | |
| SCHEMBL9790419 | 0.84 | SLC6A4 (0.46) | HTR1ADRD2DRD3KDM4EMEN1 | |
| SCHEMBL6307694 | 0.78 | HTR2A (0.43) | PARP1HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL261487 | 0.72 | PARP1 (0.64) | PARP1HTR1AHTR7HTR2BHTR6 | |
| SCHEMBL26266600 | 0.72 | MEN1 (0.52) | DRD2DRD3KDM4EMEN1MAPT | |
| SCHEMBL21510708 | 0.70 | PARP1 (0.49) | PARP1HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL10955932 | 0.70 | PARP1 (0.60) | PARP1DRD2DRD3KDM4EMAPT | |
| SCHEMBL23249538 | 0.70 | HTR1A (0.46) | HTR1AHTR2AHTR2CHTR7HTR2B | |
| SCHEMBL23248780 | 0.70 | HTR1A (0.46) | HTR1AHTR2AHTR2CHTR7HTR2B | |
| SCHEMBL23248781 | 0.70 | HTR1A (0.46) | HTR1AHTR2AHTR2CHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043387-A1 | Tricyclic indole compounds having an affinity against serotonin receptors | FUKUI YOSHIKAZU (JP) | 2005-02-24 | — | — | US | disclosed |
| US-6858640-B2 | Tricyclic indole compounds having affinity for serotonin receptor | SHIONOGI & CO., LTD. (JP) | 2005-02-22 | — | — | US | disclosed |
| US-20030236295-A1 | Tricylic indole compounds having affinity for serotonin receptor | SHIONOGI & CO., LTD. (JP) | 2003-12-25 | — | — | US | disclosed |
| EP-1325909-A1 | TRICYCLIC INDOLE COMPOUNDS HAVING AFFINITY FOR SEROTONIN RECEPTOR | SHIONOGI & CO., LTD. (JP) | 2003-07-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043387-A1 | Tricyclic indole compounds having an affinity against serotonin receptors | HTR4, TPH1, HRH4 | PARP1 2300/4885HTR1A 6/4885HTR2A 15/4885 |
| US-20030236295-A1 | Tricylic indole compounds having affinity for serotonin receptor | HTR4, HRH4, TPH1 | PARP1 2739/4885HTR1A 7/4885HTR2A 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.