Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GLP1R | P43220 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PPOX | P50336 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6306880 | 0.70 | GLP1R (0.53) | GLP1R | |
| SCHEMBL31010032 | 0.67 | HPGD (0.50) | HPGDMAPTL3MBTL1KMT2AKDM4E | |
| SCHEMBL949030 | 0.67 | HTT (0.53) | HPGDMAPTL3MBTL1KMT2AKDM4E | |
| SCHEMBL24013257 | 0.67 | KMT2A (0.45) | HPGDMAPTL3MBTL1KMT2AKDM4E | |
| SCHEMBL20804137 | 0.66 | L3MBTL1 (0.61) | HPGDMAPTL3MBTL1KMT2AKDM4E | |
| SCHEMBL31009985 | 0.65 | KMT2A (0.48) | HPGDMAPTL3MBTL1KMT2AKDM4E | |
| SCHEMBL28446155 | 0.65 | ALDH1A1 (0.58) | HPGDMAPTL3MBTL1KMT2AKDM4E | |
| SCHEMBL28932704 | 0.64 | HTT (0.68) | HPGDMAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL26830072 | 0.63 | KMT2A (0.49) | HPGDMAPTL3MBTL1KMT2AKDM4E | |
| SCHEMBL2552563 | 0.63 | GLP1R (0.66) | MAPTL3MBTL1KDM4EGLP1RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6927214-B1 | Non-peptide GLP-1 agonists | NOVO NORDISK A/S (DK) | 2005-08-09 | — | — | US | disclosed |
| EP-1147094-A1 | NON-PEPTIDE GLP-1 AGONISTS | NOVO NORDISK A/S (DK) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042026-A1 | NON-PEPTIDE GLP-1 AGONISTS | NOVO NORDISK A/S (DK) | 2000-07-20 | — | — | WO | disclosed |