Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A3 | Q92570 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312364 | 0.88 | NR4A3 (0.43) | NR4A3HSD11B1MAT2ANOTUMALDH1A1 | |
| SCHEMBL4461406 | 0.85 | SLC9A1 (0.42) | NR4A3HSD11B1MAT2ANOTUMDYRK1A | |
| Hydrochloric Acid SCHEMBL6313424 | 0.84 | SLC9A1 (0.42) | NR4A3HSD11B1MAT2ANOTUMDYRK1A | |
| SCHEMBL4461397 | 0.83 | NR4A3 (0.39) | NR4A3HSD11B1MAT2ANOTUMDYRK1A | |
| Hydrochloric Acid SCHEMBL6313420 | 0.82 | NR4A3 (0.38) | NR4A3HSD11B1MAT2ANOTUMDYRK1A | |
| SCHEMBL6313878 | 0.77 | NR4A3 (0.57) | NR4A3HSD11B1ALDH1A1MAPTFGFR1 | |
| SCHEMBL6320043 | 0.77 | NR4A3 (0.57) | NR4A3HSD11B1MAT2AKEAP1NFE2L2 | |
| SCHEMBL6313370 | 0.77 | NR4A3 (0.61) | NR4A3HSD11B1ALDH1A1MAPTFGFR1 | |
| SCHEMBL6314248 | 0.75 | NR4A3 (0.59) | NR4A3HSD11B1KEAP1NFE2L2L3MBTL1 | |
| SCHEMBL6313865 | 0.74 | NR4A3 (0.57) | NR4A3HSD11B1KEAP1NFE2L2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974813-B2 | N-[(substituted five-membered di-or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia | WARNER-LAMBERT COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | PFIZER INC. | 2003-08-07 | — | — | US | disclosed |
| US-6492401-B1 | SODIUM HYDROGEN EXCHANGER TYPE 1 INHIBITORS; REDUCING PERIOPERATIVE MYOCARDIAL TISSUE DAMAGE | PFIZER, INC. | 2002-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | NHERF1, SLC28A1, TNNI3 | NR4A3 2011/4885HSD11B1 576/4885TNKS 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.