Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A3 | Q92570 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 5/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313878 | 0.91 | NR4A3 (0.57) | NR4A3HSD11B1FGFR1FGFR2FGFR3 | |
| SCHEMBL6315637 | 0.88 | NR4A3 (0.43) | NR4A3HSD11B1FGFR1FGFR2FGFR3 | |
| SCHEMBL4452234 | 0.85 | SLC9A1 (0.42) | NR4A3HSD11B1FGFR1FGFR2FGFR3 | |
| Hydrochloric Acid SCHEMBL6313983 | 0.84 | SLC9A1 (0.42) | NR4A3HSD11B1FGFR1FGFR2FGFR3 | |
| SCHEMBL4452229 | 0.83 | NR4A3 (0.39) | NR4A3HSD11B1FGFR1FGFR2FGFR3 | |
| Hydrochloric Acid SCHEMBL6313973 | 0.82 | NR4A3 (0.38) | NR4A3HSD11B1FGFR1FGFR2FGFR3 | |
| SCHEMBL6313429 | 0.81 | NR4A3 (0.56) | NR4A3FGFR1FGFR2FGFR3SRC | |
| SCHEMBL6321394 | 0.81 | NFE2L2 (0.58) | HSD11B1KEAP1NFE2L2 | |
| SCHEMBL6315646 | 0.79 | FGFR1 (0.47) | NR4A3HSD11B1FGFR1FGFR2FGFR3 | |
| SCHEMBL6313435 | 0.76 | NR4A3 (0.56) | NR4A3FGFR1FGFR2FGFR3SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974813-B2 | N-[(substituted five-membered di-or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia | WARNER-LAMBERT COMPANY (US) | 2005-12-13 | — | — | US | disclosed |
| EP-1454902-A1 | N- (substituted five-membered di-or triaza diunsaturated ring)carbonyl guanidine derivateives for the treatment of ischemia | Pfizer Products Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | PFIZER INC. | 2003-08-07 | — | — | US | disclosed |
| US-6492401-B1 | SODIUM HYDROGEN EXCHANGER TYPE 1 INHIBITORS; REDUCING PERIOPERATIVE MYOCARDIAL TISSUE DAMAGE | PFIZER, INC. | 2002-12-10 | — | — | US | disclosed |
| EP-1056729-A1 | N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL]GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA | Pfizer Products Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043663-A1 | N-[(SUBSTITUTED FIVE-MEMBERED DI- OR TRIAZA DIUNSATURATED RING)CARBONYL] GUANIDINE DERIVATIVES FOR THE TREATMENT OF ISCHEMIA | PFIZER PRODUCTS INC. (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149043-A1 | N-[(substituted five-membered di-or triaza diunsaturated ring)carbonyl] guanidine derivatives for the treatment of ischemia | NHERF1, SLC28A1, TNNI3 | NR4A3 2011/4885HSD11B1 576/4885FGFR1 2482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.