Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | PLD2 | O14939 | 3/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653433 | 0.82 | PGR (0.46) | PGRMAPTHTR2CNR3C1NR3C2 | |
| SCHEMBL31122188 | 0.82 | PGR (0.46) | PGRMAPTHTR2CNR3C1NR3C2 | |
| SCHEMBL651526 | 0.82 | CCR2 (0.47) | PGRCYP1A2CYP2C19CCR2NR3C1 | |
| SCHEMBL13864851 | 0.82 | CCR2 (0.50) | KMT2APGRMAPTCYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL10917557 | 0.81 | PGR (0.45) | PGRMAPTHTR2CNR3C1NR3C2 | |
| SCHEMBL28606439 | 0.79 | PGR (0.47) | KMT2APGRHTR2CAKR1B1 | |
| SCHEMBL3848075 | 0.79 | PLD2 (0.47) | KMT2APGRMAPTCCR2PLD2 | |
| SCHEMBL722997 | 0.78 | BACE1 (0.47) | KMT2AMAPTPLD2PLD1 | |
| SCHEMBL22057308 | 0.78 | NPY5R (0.45) | MAPTHTR2CDPP4AKR1B1AKR1A1 | |
| Hydrochloric Acid SCHEMBL1285606 | 0.77 | MAPK1 (0.49) | KMT2AMAPTPLD2PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024229262-A1 | NARROW-SPECTRUM ANTIBIOTIC COMPOUNDS AND USES THEREOF | MCMASTER UNIVERSITY (CA) | 2024-11-07 | — | — | WO | disclosed |
| EP-2099806-B1 | SPIROPIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-02-22 | — | — | EP | disclosed |
| EP-2099806-A1 | SPIROPIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-09-16 | — | — | EP | disclosed |
| US-7470684-B2 | Spiropiperidine derivatives as NK3 antagonists | HOFFMANN-LA ROCHE INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-20080176839-A1 | SPIROPIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-24 | — | — | US | disclosed |
| WO-2008081012-A1 | SPIROPIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | WO | disclosed |
| WO-2001022919-A2 | SPIRO[BICYCLIC -AZACYCLOALKYL AND -CYCLOALKYL] DERIVATIVES AND USES THEREOF | MERCK & CO., INC. (US) | 2001-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176839-A1 | SPIROPIPERIDINE DERIVATIVES AS NK3 ANTAGONISTS | ADRB3, KCNK3, KCND3 | KMT2A 1607/4885PGR 764/4885MAPT 1645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.